7XUA
Structure of G9a in complex with compound 10a
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Histone-lysine N-methyltransferase EHMT2 | polymer | 283 | 32604.9 | 2 | UniProt (Q96KQ7) Pfam (PF05033) Pfam (PF00856) In PDB | Homo sapiens (human) | Euchromatic histone-lysine N-methyltransferase 2,HLA-B-associated transcript 8,Histone H3-K9 methyltransferase 3,H3-K9-HMTase 3,Lysine N-methyltransferase 1C,Protein G9a |
2 | A, B | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
3 | A, B | SINEFUNGIN | non-polymer | 381.4 | 2 | Chemie (SFG) | |||
4 | A, B | ~{N}-[(1~{S})-1-(1~{H}-benzimidazol-2-yl)-3-methylsulfanyl-propyl]-3,6,6-trimethyl-4-oxidanylidene-5,7-dihydro-1~{H}-indole-2-carboxamide | non-polymer | 424.6 | 2 | Chemie (I5X) | |||
5 | B | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
6 | B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
7 | water | water | 18.0 | 385 | Chemie (HOH) |
Sequence modifications
A, B: 913 - 1193 (UniProt: Q96KQ7)
PDB | External Database | Details |
---|---|---|
Gly 911 | - | expression tag |
Ser 912 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 65209.8 | |
Non-Polymers* | Number of molecules | 15 |
Total formula weight | 2381.4 | |
All* | Total formula weight | 67591.3 |