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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7XT8

Serotonin 4 (5-HT4) receptor-Gs-Nb35 complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortpolymer39445683.41UniProt (P63092)
Pfam (PF00503)		Homo sapiens (human)Adenylate cyclase-stimulating G alpha protein
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer34537915.51UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)Transducin beta chain 1
3C
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
4D
(N)		Nanobody35polymer13915271.91Lama glama
5E
(R)		Soluble cytochrome b562,5-hydroxytryptamine receptor 4polymer52759525.61UniProt (P0ABE7)
UniProt (Q13639)
Pfam (PF00001)		Homo sapiens (human)Cytochrome b-562,5-HT-4,5-HT4,Serotonin receptor 4
6F, G, H, I, J
(R)		CHOLESTEROLnon-polymer386.75Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (304)
PubChem (176980071)
PubChem (191463)
PubChem (368063)
PubChem (369319)
PubChem (18640088)
PubChem (1715243)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (1715244)
PubChem (23423981)
PubChem (45044259)
PubChem (638019)
PubChem (49853509)
PubChem (50990013)
PubChem (44654663)
PubChem (52934537)
PubChem (56621683)
PubChem (1549081)
PubChem (1553803)
PubChem (46937002)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (59450329)
PubChem (59628412)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (59274407)
PubChem (5283629)
PubChem (5284644)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (5315842)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (6419195)
PubChem (5997)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (89951918)
PubChem (90224410)
PubChem (91298236)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (11463329)
PubChem (1551269)
PubChem (90070115)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (117965027)
PubChem (6432564)
PubChem (101624109)
PubChem (6710666)
PubChem (124146240)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (10861996)
PubChem (132837164)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (124225449)
PubChem (124429284)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (138967089)
PubChem (139566851)
PubChem (130459183)
PubChem (131992107)
PubChem (15939944)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (171828367)
PubChem (173516975)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
7K, L
(R)		PALMITIC ACIDnon-polymer256.42Chemie (PLM)
8M
(R)		SEROTONINnon-polymer176.21Chemie (SRO)
Sequence modifications
A: 1 - 394 (UniProt: P63092)
PDBExternal DatabaseDetails
Asn 54Ser 54conflict
Ala 226Gly 226conflict
Ala 268Glu 268conflict
Lys 271Asn 271conflict
Asp 274Lys 274conflict
Lys 280Arg 280conflict
Asp 284Thr 284conflict
Thr 285Ile 285conflict
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -4-initiating methionine
Gly -3-expression tag
Ser -2-expression tag
Leu -1-expression tag
Leu 0-expression tag
Gln 1-expression tag
R: -116 - -12 (UniProt: P0ABE7)
PDBExternal DatabaseDetails
Asp -139-expression tag
Tyr -138-expression tag
Lys -137-expression tag
Asp -136-expression tag
Asp -135-expression tag
Asp -134-expression tag
Asp -133-expression tag
Ala -132-expression tag
Lys -131-expression tag
Leu -130-expression tag
Gln -129-expression tag
Thr -128-expression tag
Met -127-expression tag
His -126-expression tag
His -125-expression tag
His -124-expression tag
His -123-expression tag
His -122-expression tag
His -121-expression tag
His -120-expression tag
His -119-expression tag
His -118-expression tag
His -117-expression tag
Trp -110Met 29conflict
Ile -15His 124conflict
Leu -11-linker
Ala -10-linker
Ser -9-linker
Glu -8-linker
Asn -7-linker
Leu -6-linker
Tyr -5-linker
Phe -4-linker
Gln -3-linker
Gly -2-linker
Gly -1-linker
Thr 0-linker
R: 1 - 387 (UniProt: Q13639)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight166257.6
Non-Polymers*Number of molecules8
Total formula weight2622.3
All*Total formula weight168879.9
*Water molecules are not included.

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PDB entries from 2026-04-01

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