7XQY

Crystal structure of T2R-TTL-15 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Tubulin alpha-1B chain	polymer	450	50041.3	2	UniProt (Q2XVP4) Pfam (PF00091) Pfam (PF03953)	Sus scrofa (pig)	Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain
2	B, D (B, D)	Tubulin beta chain	polymer	445	49999.9	2	UniProt (A0A287AGU7) Pfam (PF00091) Pfam (PF03953) UniProt (by SIFTS) (P02554)	Sus scrofa (pig)
3	E (E)	Stathmin-4	polymer	143	16844.2	1	UniProt (P63042) Pfam (PF00836)	Mus musculus (house mouse)	Stathmin-like protein B3,RB3
4	F (F)	TTL	polymer	384	44378.5	1	UniProt (E1BQ43)	Gallus gallus (chicken)
5	G, P (A, C)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	2	Chemie (GTP)
6	H, L, Q (A, B, C)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
7	I, R (A, C)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
8	J (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
9	K, S (B, D)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
10	M, N (B)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	2	Chemie (MES)
11	O, T (B, D)	2-chloranyl-N-(4-methoxyphenyl)-N-methyl-pyrido[3,2-d]pyrimidin-4-amine	non-polymer		300.7	2	Chemie (GX5)
12	U, V, W, X, Y... (A, B, C, D, E...)	water	water		18.0	376	Chemie (HOH)

Sequence modifications

E: 5 - 145 (UniProt: P63042)

PDB	External Database	Details
Met 3	-	initiating methionine
Ala 4	-	expression tag

F: 1 - 378 (UniProt: E1BQ43)

PDB	External Database	Details
His 379	-	expression tag
His 380	-	expression tag
His 381	-	expression tag
His 382	-	expression tag
His 383	-	expression tag
His 384	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	261305.0
Non-Polymers*	Number of molecules	14
	Total formula weight	3113.2
All*	Total formula weight	264418.2

*Water molecules are not included.