7XOV
Structural insights into human brain gut peptide cholecystokinin receptors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 380 | 44284.1 | 1 | UniProt (P63092-2) Pfam (PF00503) UniProt (by SIFTS) (P63092) | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 338 | 37198.7 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (N) | Nanobody 35 | polymer | 126 | 13711.3 | 1 | synthetic construct | ||
| 5 | E (R) | Cholecystokinin receptor type A | polymer | 428 | 47886.1 | 1 | UniProt (P32238) Pfam (PF09193) Pfam (PF00001) | Homo sapiens (human) | CCK-A receptor,CCK-AR,Cholecystokinin-1 receptor,CCK1-R |
| 6 | F (R) | 2-[2-[[4-(4-chloranyl-2,5-dimethoxy-phenyl)-5-(2-cyclohexylethyl)-1,3-thiazol-2-yl]carbamoyl]-5,7-dimethyl-indol-1-yl]ethanoic acid | non-polymer | 610.2 | 1 | Chemie (IA1) | |||
| 7 | G (R) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 1 - 394 (UniProt: P63092-2)
| PDB | External Database | Details |
|---|---|---|
| Asn 54 | Ser 54 | engineered mutation |
| Ala 226 | Gly 212 | engineered mutation |
| Ala 268 | Glu 254 | engineered mutation |
| Lys 271 | Asn 257 | engineered mutation |
| Asp 274 | Lys 260 | engineered mutation |
| Lys 280 | Arg 266 | engineered mutation |
| Asp 284 | Thr 270 | engineered mutation |
| Thr 285 | Ile 271 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 150941.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 610.2 | |
| All* | Total formula weight | 151551.4 |
