7XOU
Structural insights into human brain gut peptide cholecystokinin receptors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | CCK-8 | polymer | 9 | 1142.3 | 1 | UniProt (by SIFTS) (P06307) | Homo sapiens | |
| 2 | B (A) | Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 380 | 44284.1 | 1 | UniProt (P63092-2) Pfam (PF00503) UniProt (by SIFTS) (P63092) | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein |
| 3 | C (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 384 | 41729.6 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (N) | Nanobody 35 | polymer | 126 | 13711.3 | 1 | synthetic construct | ||
| 6 | F (R) | Cholecystokinin receptor type A | polymer | 428 | 47886.1 | 1 | UniProt (P32238) Pfam (PF09193) Pfam (PF00001) | Homo sapiens (human) | CCK-A receptor,CCK-AR,Cholecystokinin-1 receptor,CCK1-R |
Sequence modifications
A: 1 - 394 (UniProt: P63092-2)
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Asn 54 | Ser 54 | engineered mutation |
| Ala 226 | Gly 212 | engineered mutation |
| Ala 268 | Glu 254 | engineered mutation |
| Lys 271 | Asn 257 | engineered mutation |
| Asp 274 | Lys 260 | engineered mutation |
| Lys 280 | Arg 266 | engineered mutation |
| Asp 284 | Thr 270 | engineered mutation |
| Thr 285 | Ile 271 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -17 | - | initiating methionine |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Leu -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Val -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| Gly 341 | - | expression tag |
| Ser 342 | - | expression tag |
| Ser 343 | - | expression tag |
| Gly 344 | - | expression tag |
| Gly 345 | - | expression tag |
| Gly 346 | - | expression tag |
| Gly 347 | - | expression tag |
| Ser 348 | - | expression tag |
| Gly 349 | - | expression tag |
| Gly 350 | - | expression tag |
| Gly 351 | - | expression tag |
| Gly 352 | - | expression tag |
| Ser 353 | - | expression tag |
| Ser 354 | - | expression tag |
| Gly 355 | - | expression tag |
| Val 356 | - | expression tag |
| Ser 357 | - | expression tag |
| Gly 358 | - | expression tag |
| Trp 359 | - | expression tag |
| Arg 360 | - | expression tag |
| Leu 361 | - | expression tag |
| Phe 362 | - | expression tag |
| Lys 363 | - | expression tag |
| Lys 364 | - | expression tag |
| Ile 365 | - | expression tag |
| Ser 366 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 156614.4 | |
| All* | Total formula weight | 156614.4 |
