7XOE

Cryo-EM structure of S glycoprotein encoded by the Covid-19 mRNA vaccine candidate RQ3013 (Prefusion state)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Spike glycoprotein,peptide	polymer	1293	142819.8	3	UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601)	Severe acute respiratory syndrome coronavirus	S glycoprotein,E2,Peplomer protein
2	D, E, F, G, H... (D, E, F, G, H...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	12	In PDB GlyTouCan (G42666HT)
3	AA, BA, CA, DA, EA... (B, C, A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	21	Chemie (NAG)

Sequence modifications

A, B, C: 1 - 1252 (UniProt: P0DTC2)

PDB	External Database	Details
-	His 69	deletion
-	Val 70	deletion
-	Tyr 144	deletion
Asn 414	Lys 417	variant
Lys 481	Glu 484	variant
Tyr 498	Asn 501	variant
Asp 567	Ala 570	variant
Gly 611	Asp 614	variant
His 678	Pro 681	variant
Gly 679	Arg 682	conflict
Ser 680	Arg 683	conflict
Ser 682	Arg 685	conflict
Val 698	Ala 701	variant
Ile 713	Thr 716	variant
Ala 979	Ser 982	variant
His 1115	Asp 1118	variant

A, B, C: 1253 - 1293 (PDB: 7XOE)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	428459.4
Branched	Number of molecules	12
	Total formula weight	5092.8
Non-Polymers*	Number of molecules	21
	Total formula weight	4645.4
All*	Total formula weight	438197.6

*Water molecules are not included.