7XNQ

SARS-CoV-2 Omicron BA.4 variant spike

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Spike glycoprotein	polymer	1268	140836.2	3	UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)	S glycoprotein,E2,Peplomer protein
2	D, E, F, G, H...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	18	In PDB GlyTouCan (G42666HT)
3	A, C, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	33	Chemie (NAG)

Sequence modifications

A, B, C: 4 - 1271 (UniProt: P0DTC2)

PDB	External Database	Details
Ile 22	Thr 19	variant
-	Leu 24	deletion
-	Pro 25	deletion
-	Pro 26	deletion
Ser 27	Ala 27	variant
-	His 69	deletion
-	Val 70	deletion
Asp 140	Gly 142	variant
Gly 211	Val 213	variant
Asp 337	Gly 339	variant
Phe 369	Ser 371	variant
Pro 371	Ser 373	variant
Phe 373	Ser 375	variant
Ala 374	Thr 376	variant
Asn 403	Asp 405	variant
Ser 406	Arg 408	variant
Asn 415	Lys 417	variant
Lys 438	Asn 440	variant
Arg 450	Leu 452	variant
Asn 475	Ser 477	variant
Lys 476	Thr 478	variant
Ala 482	Glu 484	variant
Val 484	Phe 486	variant
Arg 496	Gln 498	variant
Tyr 499	Asn 501	variant
His 503	Tyr 505	variant
Gly 612	Asp 614	variant
Tyr 653	His 655	variant
Ser 656	Asn 658	variant
Lys 677	Asn 679	variant
His 679	Pro 681	variant
Ala 681	Arg 683	variant
Ala 683	Arg 685	variant
Lys 762	Asn 764	variant
Tyr 794	Asp 796	variant
Pro 815	Phe 817	variant
Pro 890	Ala 892	variant
Pro 897	Ala 899	variant
Pro 940	Ala 942	variant
His 952	Gln 954	variant
Lys 967	Asn 969	variant
Pro 984	Lys 986	engineered mutation
Pro 985	Val 987	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	422508.5
Branched	Number of molecules	18
	Total formula weight	7639.2
Non-Polymers*	Number of molecules	33
	Total formula weight	7299.9
All*	Total formula weight	437447.5

*Water molecules are not included.