7XNG

Crystal structure of CBP bromodomain liganded with Y08092(31g)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	CREB-binding protein	polymer	133	15891.3	2	UniProt (Q92793) Pfam (PF00439)	Homo sapiens (human)
2	C, F (A, B)	3-[(1-ethanoylindol-3-yl)carbonylamino]-5-[[(2S)-oxan-2-yl]oxymethyl]benzoic acid	non-polymer		436.5	2	Chemie (GI5)
3	D (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	E (B)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
5	G, H (A, B)	water	water		18.0	46	Chemie (HOH)

Sequence modifications

A, B: 1081 - 1197 (UniProt: Q92793)

PDB	External Database	Details
Met 1065	-	expression tag
Lys 1066	-	expression tag
Lys 1067	-	expression tag
Gly 1068	-	expression tag
His 1069	-	expression tag
His 1070	-	expression tag
His 1071	-	expression tag
His 1072	-	expression tag
His 1073	-	expression tag
His 1074	-	expression tag
Leu 1075	-	expression tag
Val 1076	-	expression tag
Pro 1077	-	expression tag
Arg 1078	-	expression tag
Gly 1079	-	expression tag
Ser 1080	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	31782.6
Non-Polymers*	Number of molecules	4
	Total formula weight	1071.1
All*	Total formula weight	32853.7

*Water molecules are not included.