7XNA

Crystal structure of somatostatin receptor 2 (SSTR2) with peptide antagonist CYN 154806

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Somatostatin receptor type 2,Endo-1,4-beta-xylanase	polymer	583	65500.6	1	UniProt (P30874) UniProt (P09850) Pfam (PF00001) Pfam (PF00457)	Homo sapiens (human)	SS-2-R,SS2-R,SS2R,SRIF-1,SSTR2,Xylanase,1,4-beta-D-xylan xylanohydrolase
2	B (B)	CYN 154806	polymer	10	1183.4	1		synthetic construct

Sequence modifications

A: 2 - 237 (UniProt: P30874)

PDB	External Database	Details
Met -24	-	expression tag
Lys -23	-	expression tag
Thr -22	-	expression tag
Ile -21	-	expression tag
Ile -20	-	expression tag
Ala -19	-	expression tag
Leu -18	-	expression tag
Ser -17	-	expression tag
Tyr -16	-	expression tag
Ile -15	-	expression tag
Phe -14	-	expression tag
Cys -13	-	expression tag
Leu -12	-	expression tag
Val -11	-	expression tag
Phe -10	-	expression tag
Ala -9	-	expression tag
Asp -8	-	expression tag
Tyr -7	-	expression tag
Lys -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Gly -1	-	expression tag
Ala 0	-	expression tag
Pro 1	-	expression tag
Asn 89	Asp 89	conflict
Glu 106	Val 106	conflict

A: 1000 - 1184 (UniProt: P09850)

PDB	External Database	Details
Phe 1010	Asp 39	conflict
Asp 1121	Arg 150	conflict

A: 244 - 359 (UniProt: P30874)

PDB	External Database	Details
Asp 316	Ser 316	conflict
Glu 360	-	expression tag
Phe 361	-	expression tag
Leu 362	-	expression tag
Glu 363	-	expression tag
Val 364	-	expression tag
Leu 365	-	expression tag
Phe 366	-	expression tag
Gln 367	-	expression tag
Gly 368	-	expression tag
Pro 369	-	expression tag
His 370	-	expression tag
His 371	-	expression tag
His 372	-	expression tag
His 373	-	expression tag
His 374	-	expression tag
His 375	-	expression tag
His 376	-	expression tag
His 377	-	expression tag
His 378	-	expression tag
His 379	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	66684.0
All*	Total formula weight	66684.0

*Water molecules are not included.