7XMG
Cryo-EM structure of human NaV1.7/beta1/beta2-TCN-1752
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform 3 of Sodium channel protein type 9 subunit alpha,Green fluorescent protein | polymer | 2250 | 255679.9 | 1 | UniProt (Q15858) Pfam (PF00520) Pfam (PF11933) Pfam (PF06512) Pfam (PF08016) | Homo sapiens (human) | Neuroendocrine sodium channel,hNE-Na,Peripheral sodium channel 1,PN1,Sodium channel protein type IX subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.7 |
| 2 | B (B) | Sodium channel subunit beta-1,Green fluorescent protein | polymer | 481 | 54472.1 | 1 | UniProt (Q07699) Pfam (PF07686) | Homo sapiens (human) | |
| 3 | C (F) | Sodium channel subunit beta-2 | polymer | 215 | 24355.9 | 1 | UniProt (O60939) Pfam (PF07686) | Homo sapiens (human) | Nav1.7 beta2 subunit |
| 4 | D, E (D, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 5 | F, H, I, J, K (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 6 | G (A) | (1~{Z})-~{N}-[2-methyl-3-[(~{E})-[6-[4-[[4-(trifluoromethyloxy)phenyl]methoxy]piperidin-1-yl]-1~{H}-1,3,5-triazin-2-ylidene]amino]phenyl]ethanimidic acid | non-polymer | 516.5 | 1 | Chemie (G4I) |
Sequence modifications
A: 1 - 1988 (UniProt: Q15858)
A: 2001 - 2261 (PDB: 7XMG)
B: 1 - 218 (UniProt: Q07699)
B: 231 - 481 (PDB: 7XMG)
| PDB | External Database | Details |
|---|---|---|
| Arg 1161 | Trp 1150 | engineered mutation |
| Ala 1989 | - | linker |
| Ala 1990 | - | linker |
| Ala 1991 | - | linker |
| Leu 1992 | - | linker |
| Glu 1993 | - | linker |
| Val 1994 | - | linker |
| Leu 1995 | - | linker |
| Phe 1996 | - | linker |
| Gln 1997 | - | linker |
| Gly 1998 | - | linker |
| Pro 1999 | - | linker |
| Ser 2000 | - | linker |
B: 1 - 218 (UniProt: Q07699)
| PDB | External Database | Details |
|---|---|---|
| Ala 219 | - | linker |
| Ala 220 | - | linker |
| Ala 221 | - | linker |
| Leu 222 | - | linker |
| Glu 223 | - | linker |
| Val 224 | - | linker |
| Leu 225 | - | linker |
| Phe 226 | - | linker |
| Gln 227 | - | linker |
| Gly 228 | - | linker |
| Pro 229 | - | linker |
| Ser 230 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 334507.9 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1622.6 | |
| All* | Total formula weight | 336979.3 |
