7XM9
Cryo-EM structure of human NaV1.7/beta1/beta2-XEN907
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Isoform 3 of Sodium channel protein type 9 subunit alpha,Green fluorescent protein | polymer | 2250 | 255679.9 | 1 | UniProt (Q15858) Pfam (PF00520) Pfam (PF11933) Pfam (PF06512) Pfam (PF08016) In PDB | Homo sapiens (human) | Neuroendocrine sodium channel,hNE-Na,Peripheral sodium channel 1,PN1,Sodium channel protein type IX subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.7 |
| 2 | B | Sodium channel subunit beta-1,Green fluorescent protein | polymer | 481 | 54472.1 | 1 | UniProt (Q07699) Pfam (PF07686) In PDB | Homo sapiens (human) | |
| 3 | C | Sodium channel subunit beta-2 | polymer | 215 | 24355.9 | 1 | UniProt (O60939) Pfam (PF07686) In PDB | Homo sapiens (human) | Nav1.7 beta2 subunit |
| 4 | D, E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 5 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 6 | A | (7~{R})-1'-pentylspiro[6~{H}-furo[3,2-f][1,3]benzodioxole-7,3'-indole]-2'-one | non-polymer | 351.4 | 1 | Chemie (G2E) | |||
| 7 | A | [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | non-polymer | 718.0 | 1 | Chemie (6OU) |
Sequence modifications
A: 1 - 1988 (UniProt: Q15858)
A: 2001 - 2261 (PDB: 7XM9)
B: 1 - 218 (UniProt: Q07699)
B: 231 - 481 (PDB: 7XM9)
| PDB | External Database | Details |
|---|---|---|
| Arg 1161 | Trp 1150 | engineered mutation |
| Ala 1989 | - | linker |
| Ala 1990 | - | linker |
| Ala 1991 | - | linker |
| Leu 1992 | - | linker |
| Glu 1993 | - | linker |
| Val 1994 | - | linker |
| Leu 1995 | - | linker |
| Phe 1996 | - | linker |
| Gln 1997 | - | linker |
| Gly 1998 | - | linker |
| Pro 1999 | - | linker |
| Ser 2000 | - | linker |
B: 1 - 218 (UniProt: Q07699)
| PDB | External Database | Details |
|---|---|---|
| Ala 219 | - | linker |
| Ala 220 | - | linker |
| Ala 221 | - | linker |
| Leu 222 | - | linker |
| Glu 223 | - | linker |
| Val 224 | - | linker |
| Leu 225 | - | linker |
| Phe 226 | - | linker |
| Gln 227 | - | linker |
| Gly 228 | - | linker |
| Pro 229 | - | linker |
| Ser 230 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 334507.9 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2175.4 | |
| All* | Total formula weight | 337532.1 |
