7XJK
Cryo-EM structure of the galanin-bound GALR2-miniGq complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Galanin | polymer | 30 | 3161.4 | 1 | UniProt (P22466) Pfam (PF01296) In PDB | Homo sapiens (human) | |
2 | B | Guanine nucleotide-binding protein G(q) | polymer | 246 | 28026.8 | 1 | Homo sapiens | ||
3 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 348 | 38389.9 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
4 | D | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7845.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
5 | E | single Fab chain (svFv16) | polymer | 300 | 32071.6 | 1 | Homo sapiens | ||
6 | F | Galanin receptor type 2 | polymer | 332 | 36401.9 | 1 | UniProt (O43603) Pfam (PF00001) In PDB | Homo sapiens (human) | GAL2-R,GALR-2 |
Sequence modifications
C: 1 - 340 (UniProt: P62873)
D: 1 - 71 (UniProt: P59768)
F: 1 - 314 (UniProt: O43603)
PDB | External Database | Details |
---|---|---|
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ser 68 | Cys 68 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Asp -9 | - | expression tag |
Tyr -8 | - | expression tag |
Lys -7 | - | expression tag |
Asp -6 | - | expression tag |
Asp -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Lys -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Gln 165 | Arg 165 | conflict |
Gly 315 | - | expression tag |
Ser 316 | - | expression tag |
Leu 317 | - | expression tag |
Glu 318 | - | expression tag |
Val 319 | - | expression tag |
Leu 320 | - | expression tag |
Phe 321 | - | expression tag |
Gln 322 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 145896.7 | |
All* | Total formula weight | 145896.7 |