7XJ4
Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with nitrofuran methoxy(methoxycarbonyl)phenyl ester
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Reverse Transcriptase RNase H domain | polymer | 151 | 16832.3 | 1 | UniProt (A0A059PIR4) UniProt (A0A7L9QW77) Pfam (PF00075) UniProt (by SIFTS) (P04585) | Human immunodeficiency virus 1 | |
| 2 | B, C (A) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 3 | D, E, G (A) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 4 | F (A) | S-[5-[(E)-2-phenylethenyl]-1,3,4-oxadiazol-2-yl] 5-nitrothiophene-2-carbothioate | non-polymer | 359.4 | 1 | Chemie (E9B) | |||
| 5 | H (A) | water | water | 18.0 | 16 | Chemie (HOH) |
Sequence modifications
A: 7 - 80 (UniProt: A0A059PIR4)
A: 106 - 151 (UniProt: A0A7L9QW77)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Pro 2 | - | expression tag |
| Gly 3 | - | expression tag |
| Gly 4 | - | expression tag |
| Ser 5 | - | expression tag |
| Met 6 | - | expression tag |
| Tyr 81 | - | linker |
| Ala 82 | - | linker |
| Leu 83 | - | linker |
| Gly 84 | - | linker |
| Ile 85 | - | linker |
| Ile 86 | - | linker |
| Thr 87 | - | linker |
| Gln 88 | - | linker |
| Trp 89 | - | linker |
| Ile 90 | - | linker |
| His 91 | - | linker |
| Asn 92 | - | linker |
| Trp 93 | - | linker |
| Lys 94 | - | linker |
| Lys 95 | - | linker |
| Arg 96 | - | linker |
| Gly 97 | - | linker |
| Trp 98 | - | linker |
| Lys 99 | - | linker |
| Thr 100 | - | linker |
| Pro 101 | - | linker |
| Val 102 | - | linker |
| Lys 103 | - | linker |
| Asn 104 | - | linker |
| Val 105 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 16832.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 665.5 | |
| All* | Total formula weight | 17497.8 |
