7XIJ

Crystal structure of CBP bromodomain liganded with Y08175

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Isoform 2 of CREB-binding protein	polymer	136	16276.6	1	UniProt (Q92793) Pfam (PF00439) In PDB	Homo sapiens (human)	Histone lysine acetyltransferase CREBBP,Protein-lysine acetyltransferase CREBBP
2	A	3-[(1-ethanoyl-5-methoxy-indol-3-yl)carbonylamino]-4-fluoranyl-5-(1-methylpyrazol-4-yl)benzoic acid	non-polymer		450.4	1	Chemie (EJ3)
3	A	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS)
4	A	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5		water	water		18.0	93	Chemie (HOH)

Sequence modifications

A: 1081 - 1197 (UniProt: Q92793)

PDB	External Database	Details
Met 1062	-	initiating methionine
Lys 1063	-	expression tag
Lys 1064	-	expression tag
Gly 1065	-	expression tag
His 1066	-	expression tag
His 1067	-	expression tag
His 1068	-	expression tag
His 1069	-	expression tag
His 1070	-	expression tag
His 1071	-	expression tag
Glu 1072	-	expression tag
Asn 1073	-	expression tag
Leu 1074	-	expression tag
Tyr 1075	-	expression tag
Phe 1076	-	expression tag
Gln 1077	-	expression tag
Gly 1078	-	expression tag
Gly 1079	-	expression tag
Ser 1080	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	16276.6
Non-Polymers*	Number of molecules	4
	Total formula weight	712.7
All*	Total formula weight	16989.3

*Water molecules are not included.