7XHQ
Small-molecule Allosteric Regulation Mechanism of SHP2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein phosphatase non-receptor type 11 | polymer | 525 | 60248.0 | 2 | UniProt (Q06124) Pfam (PF00017) Pfam (PF00102) | Homo sapiens (human) | SH-PTP2,SHP-2,Shp2 |
| 2 | C, D (A, B) | 2-[(3S,4R)-4-azanyl-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-5-[2,3-bis(chloranyl)phenyl]-3-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-one | non-polymer | 462.4 | 2 | Chemie (FIZ) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 470 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 120495.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 924.7 | |
| All* | Total formula weight | 121420.7 |
