7XHO

Structure of human inner kinetochore CCAN complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, O (C, c)	Centromere protein C	polymer	943	107022.3	2	UniProt (Q03188) Pfam (PF15622) Pfam (PF15620) Pfam (PF11699)	Homo sapiens (human)	CENP-C,Centromere autoantigen C,Centromere protein C 1,CENP-C 1,Interphase centromere complex protein 7
2	B (H)	Centromere protein H	polymer	247	28520.9	1	UniProt (Q9H3R5) Pfam (PF05837)	Homo sapiens (human)	CENP-H,Interphase centromere complex protein 35
3	C (I)	Centromere protein I	polymer	756	86820.2	1	UniProt (Q92674) Pfam (PF07778)	Homo sapiens (human)	CENP-I,FSH primary response protein 1,Follicle-stimulating hormone primary response protein,Interphase centromere complex protein 19,Leucine-rich primary response protein 1
4	D (K)	Centromere protein K	polymer	269	31696.1	1	UniProt (Q9BS16) Pfam (PF11802)	Homo sapiens (human)	CENP-K,Interphase centromere complex protein 37,Protein AF-5alpha,p33
5	E (L)	Centromere protein L	polymer	344	39040.6	1	UniProt (Q8N0S6) Pfam (PF13092)	Homo sapiens (human)	CENP-L,Interphase centromere complex protein 33
6	F (M)	Centromere protein M	polymer	180	19761.9	1	UniProt (Q9NSP4) Pfam (PF11111)	Homo sapiens (human)	CENP-M,Interphase centromere complex protein 39,Proliferation-associated nuclear element protein 1
7	G (N)	Centromere protein N	polymer	339	39595.5	1	UniProt (Q96H22) Pfam (PF05238)	Homo sapiens (human)	CENP-N,Interphase centromere complex protein 32
8	H (O)	Centromere protein O	polymer	300	33830.6	1	UniProt (Q9BU64) Pfam (PF09496)	Homo sapiens (human)	CENP-O,Interphase centromere complex protein 36
9	I (P)	Centromere protein P	polymer	288	33210.9	1	UniProt (Q6IPU0) Pfam (PF13096)	Homo sapiens (human)	CENP-P
10	J (Q)	Centromere protein Q	polymer	268	30648.4	1	UniProt (Q7L2Z9) Pfam (PF13094)	Homo sapiens (human)	CENP-Q
11	K (S)	Centromere protein S	polymer	138	15917.9	1	UniProt (Q8N2Z9) Pfam (PF15630)	Homo sapiens (human)	CENP-S,Apoptosis-inducing TAF9-like domain-containing protein 1,FANCM-associated histone fold protein 1,FANCM-interacting histone fold protein 1,Fanconi anemia-associated polypeptide of 16 kDa
12	L (T)	Centromere protein T	polymer	561	60502.6	1	UniProt (Q96BT3) Pfam (PF16171) Pfam (PF15511)	Homo sapiens (human)	CENP-T,Interphase centromere complex protein 22
13	M (W)	CENP-W	polymer	88	10087.2	1	UniProt (Q5EE01) Pfam (PF15510)	Homo sapiens (human)
14	N (X)	Centromere protein X	polymer	81	8972.4	1	UniProt (A8MT69) Pfam (PF09415)	Homo sapiens (human)	CENP-X,FANCM-associated histone fold protein 2,FANCM-interacting histone fold protein 2,Fanconi anemia-associated polypeptide of 10 kDa,Retinoic acid-inducible gene D9 protein homolog,Stimulated by retinoic acid gene 13 protein homolog
15	P (R)	Centromere protein R	polymer	177	20228.3	1	UniProt (Q13352) Pfam (PF06729)	Homo sapiens (human)	CENP-R,Beta-3-endonexin,Integrin beta-3-binding protein,Nuclear receptor-interacting factor 3
16	Q (U)	Centromere protein U	polymer	418	47609.8	1	UniProt (Q71F23) Pfam (PF13097)	Homo sapiens (human)	CENP-U,Centromere protein of 50 kDa,CENP-50,Interphase centromere complex protein 24,KSHV latent nuclear antigen-interacting protein 1,MLF1-interacting protein,Polo-box-interacting protein 1

Sequence modifications

L: 1 - 344 (UniProt: Q8N0S6)

PDB	External Database	Details
Asp 116	Asn 116	engineered mutation

N: 1 - 339 (UniProt: Q96H22)

PDB	External Database	Details
Asp 84	Glu 84	variant

Contents of the asymmetric unit

Polymers	Number of chains	17
	Total formula weight	720488.0
All*	Total formula weight	720488.0

*Water molecules are not included.