7XHK
High-resolution X-ray cocrystal structure of USP7 in complex with LX04-46
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B | Ubiquitin carboxyl-terminal hydrolase 7 | polymer | 348 | 40268.4 | 1 | UniProt (Q93009) Pfam (PF00443) In PDB | Homo sapiens (human) | Deubiquitinating enzyme 7,Herpesvirus-associated ubiquitin-specific protease,Ubiquitin thioesterase 7,Ubiquitin-specific-processing protease 7 |
| 2 | B | ~{N}-[[4-[6-[[1-[[2-chloranyl-4-(furan-2-yl)phenyl]methyl]-4-oxidanyl-piperidin-4-yl]methyl]-2-methyl-7-oxidanylidene-pyrazolo[4,3-d]pyrimidin-3-yl]phenyl]methyl]methanamide | non-polymer | 587.1 | 1 | Chemie (DVU) | |||
| 3 | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
B: 211 - 553 (UniProt: Q93009)
| PDB | External Database | Details |
|---|---|---|
| Ser 207 | - | expression tag |
| Lys 208 | - | expression tag |
| Lys 209 | - | expression tag |
| His 210 | - | expression tag |
| His 410 | Met 410 | conflict |
| Lys 554 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40268.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 587.1 | |
| All* | Total formula weight | 40855.5 |
