7XGG

Crystal structure of BCL-xL in complex with computationally designed inhibitor protein

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, F, C, E	Bcl-2-like protein 1	polymer	172	19827.2	4	UniProt (Q07817) Pfam (PF02180) Pfam (PF00452) In PDB	Homo sapiens (human)	Bcl2-L-1,Apoptosis regulator Bcl-X
2	A, D	BCL-xL and MCL-1 dual inhibitor	polymer	164	18600.2	2		synthetic construct
3		water	water		18.0	536	Chemie (HOH)

Sequence modifications

B, F, C, E: 4 - 47 (UniProt: Q07817)

PDB	External Database	Details
Gly 1	-	expression tag
His 2	-	expression tag
Mse 3	-	expression tag

B, F, C, E: 48 - 172 (UniProt: Q07817)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	116509.2
All*	Total formula weight	116509.2

*Water molecules are not included.