7XDL
Cryo-EM structure of SARS-CoV-2 Delta Spike protein in complex with BA7208 and BA7125 fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Spike glycoprotein | polymer | 1116 | 123251.6 | 3 | UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB | Severe acute respiratory syndrome coronavirus 2 | S glycoprotein,E2,Peplomer protein |
| 2 | D, F, H | BA7125 fab | polymer | 211 | 22882.4 | 3 | Homo sapiens | ||
| 3 | E, G, I | BA7125 fab | polymer | 215 | 22978.7 | 3 | Homo sapiens | ||
| 4 | J, L, O | BA7208 fab | polymer | 105 | 11515.7 | 3 | Homo sapiens | ||
| 5 | K, M, P | BA7208 fab | polymer | 120 | 13398.0 | 3 | Homo sapiens | ||
| 6 | a, N, Q, R, S... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 12 | In PDB GlyTouCan (G42666HT) | |||
| 7 | A, B, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 12 | Chemie (NAG) |
Sequence modifications
A, B, C: 11 - 1126 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| - | Glu 156 | deletion |
| - | Phe 157 | deletion |
| Gly 141 | Arg 158 | conflict |
| Arg 435 | Leu 452 | conflict |
| Lys 461 | Thr 478 | conflict |
| Gly 597 | Asp 614 | conflict |
| Gly 665 | Arg 682 | conflict |
| Ser 666 | Arg 683 | conflict |
| Ser 668 | Arg 685 | conflict |
| Pro 875 | Ala 892 | conflict |
| Pro 882 | Ala 899 | conflict |
| Pro 925 | Ala 942 | conflict |
| Asn 933 | Asp 950 | conflict |
| Pro 969 | Lys 986 | conflict |
| Pro 970 | Val 987 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 15 |
| Total formula weight | 582079.0 | |
| Branched | Number of molecules | 12 |
| Total formula weight | 5092.8 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2654.5 | |
| All* | Total formula weight | 589826.3 |
