7XCR
Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 1:1 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Ubiquitin | polymer | 76 | 8576.8 | 1 | UniProt (P0CG47) Pfam (PF00240) | Homo sapiens (human) | |
| 2 | B, J (F, B) | Histone H4 | polymer | 88 | 10061.8 | 2 | UniProt (A0A672GII6) Pfam (PF15511) UniProt (by SIFTS) (P62805) | Homo sapiens (human) | |
| 3 | C, I (G, C) | Histone H2A | polymer | 108 | 11865.9 | 2 | UniProt (Q08AJ9) Pfam (PF00125) Pfam (PF16211) UniProt (by SIFTS) (P04908) | Homo sapiens (human) | |
| 4 | D, H (H, D) | Histone H2B type 1-K | polymer | 94 | 10478.0 | 2 | UniProt (O60814) Pfam (PF00125) | Homo sapiens (human) | H2B K,HIRA-interacting protein 1 |
| 5 | E (K) | Histone-lysine N-methyltransferase, H3 lysine-79 specific | polymer | 328 | 37930.0 | 1 | UniProt (Q8TEK3) Pfam (PF08123) | Homo sapiens (human) | DOT1-like protein |
| 6 | F, G (E, A) | Histone domain-containing protein | polymer | 99 | 11615.6 | 2 | UniProt (S4RAZ3) Pfam (PF00125) UniProt (by SIFTS) (Q71DI3) | synthetic construct | |
| 7 | K (I) | DNA (146-MER) | polymer | 146 | 44825.6 | 1 | synthetic construct | ||
| 8 | L (J) | DNA (146-MER) | polymer | 146 | 45305.9 | 1 | synthetic construct | ||
| 9 | M (K) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) |
Sequence modifications
E, A: 37 - 135 (UniProt: S4RAZ3)
| PDB | External Database | Details |
|---|---|---|
| Nle 79 | Lys 103 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 224680.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 398.4 | |
| All* | Total formula weight | 225079.3 |
