7X9Y
Cryo-EM structure of the apo CCR3-Gi complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40414.0 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 339 | 37285.7 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (R) | C-C chemokine receptor type 3 | polymer | 355 | 41044.6 | 1 | UniProt (P51677) Pfam (PF00001) | Homo sapiens (human) | C C CKR3,C-C CKR-3,CC-CKR-3,CCR-3,CCR3,CKR 3,CKR3,Eosinophil eotaxin receptor |
| 5 | E (S) | scFv16 | polymer | 247 | 26293.3 | 1 | Homo sapiens |
Sequence modifications
A: 7 - 762 (UniProt: P63096)
R: 1 - 387 (UniProt: P51677)
| PDB | External Database | Details |
|---|---|---|
| Asn 53 | Ser 47 | engineered mutation |
| Ala 611 | Gly 203 | engineered mutation |
| Ala 653 | Glu 245 | engineered mutation |
| Ser 734 | Ala 326 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 244 | Ile 244 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 152898.8 | |
| All* | Total formula weight | 152898.8 |
