7X9A
Cryo-EM structure of neuropeptide Y Y1 receptor in complex with NPY and Gi
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Neuropeptide Y receptor type 1 | polymer | 378 | 43462.6 | 1 | UniProt (P25929) Pfam (PF00001) | Homo sapiens (human) | NPY1-R |
| 2 | B (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40414.0 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 3 | C (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 351 | 38744.4 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 4 | D (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | Pfam (PF00631) UniProt (by SIFTS) (P59768) | Homo sapiens | |
| 5 | E (P) | Neuropeptide Y | polymer | 36 | 4277.7 | 1 | UniProt (P01303) Pfam (PF00159) | Homo sapiens | Neuropeptide tyrosine,NPY |
Sequence modifications
R: 1 - 340 (UniProt: P25929)
A: 1 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Glu 341 | - | expression tag |
| Phe 342 | - | expression tag |
| Leu 343 | - | expression tag |
| Glu 344 | - | expression tag |
| Val 345 | - | expression tag |
| Leu 346 | - | expression tag |
| Phe 347 | - | expression tag |
| Gln 348 | - | expression tag |
| Gly 349 | - | expression tag |
| Pro 350 | - | expression tag |
| Trp 351 | - | expression tag |
| Ser 352 | - | expression tag |
| His 353 | - | expression tag |
| Pro 354 | - | expression tag |
| Gln 355 | - | expression tag |
| Phe 356 | - | expression tag |
| Glu 357 | - | expression tag |
| Lys 358 | - | expression tag |
| Gly 359 | - | expression tag |
| Gly 360 | - | expression tag |
| Gly 361 | - | expression tag |
| Ser 362 | - | expression tag |
| Gly 363 | - | expression tag |
| Gly 364 | - | expression tag |
| Gly 365 | - | expression tag |
| Ser 366 | - | expression tag |
| Gly 367 | - | expression tag |
| Gly 368 | - | expression tag |
| Ser 369 | - | expression tag |
| Ala 370 | - | expression tag |
| Trp 371 | - | expression tag |
| Ser 372 | - | expression tag |
| His 373 | - | expression tag |
| Pro 374 | - | expression tag |
| Gln 375 | - | expression tag |
| Phe 376 | - | expression tag |
| Glu 377 | - | expression tag |
| Lys 378 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asn 47 | Ser 47 | engineered mutation |
| Ala 203 | Gly 203 | engineered mutation |
| Ala 245 | Glu 245 | engineered mutation |
| Ser 326 | Ala 326 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -10 | - | initiating methionine |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 134759.9 | |
| All* | Total formula weight | 134759.9 |
