7X8Z

The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab188

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Spike glycoprotein	polymer	1278	141459.5	1	UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB	Severe acute respiratory syndrome coronavirus 2	S glycoprotein,E2,Peplomer protein
2	H	Ab188 heavy chain	polymer	265	28637.1	1		Severe acute respiratory syndrome coronavirus 2
3	L	Ab188 light chain	polymer	248	27390.5	1		Severe acute respiratory syndrome coronavirus 2
4	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)

Sequence modifications

A: 1 - 1208 (UniProt: P0DTC2)

PDB	External Database	Details
Gly 682	Arg 682	engineered mutation
Ser 683	Arg 683	engineered mutation
Ser 685	Arg 685	engineered mutation
Pro 817	Phe 817	engineered mutation
Pro 892	Ala 892	engineered mutation
Pro 899	Ala 899	engineered mutation
Pro 942	Ala 942	engineered mutation
Pro 986	Lys 986	engineered mutation
Pro 987	Val 987	engineered mutation
Ala 1209	-	expression tag
Ala 1210	-	expression tag
Ala 1211	-	expression tag
Gly 1212	-	expression tag
Ser 1213	-	expression tag
Gly 1214	-	expression tag
Tyr 1215	-	expression tag
Ile 1216	-	expression tag
Pro 1217	-	expression tag
Glu 1218	-	expression tag
Ala 1219	-	expression tag
Pro 1220	-	expression tag
Arg 1221	-	expression tag
Asp 1222	-	expression tag
Gly 1223	-	expression tag
Gln 1224	-	expression tag
Ala 1225	-	expression tag
Tyr 1226	-	expression tag
Val 1227	-	expression tag
Arg 1228	-	expression tag
Lys 1229	-	expression tag
Asp 1230	-	expression tag
Gly 1231	-	expression tag
Glu 1232	-	expression tag
Trp 1233	-	expression tag
Val 1234	-	expression tag
Leu 1235	-	expression tag
Leu 1236	-	expression tag
Ser 1237	-	expression tag
Thr 1238	-	expression tag
Phe 1239	-	expression tag
Leu 1240	-	expression tag
Gly 1241	-	expression tag
Ser 1242	-	expression tag
Ser 1243	-	expression tag
Gly 1244	-	expression tag
Arg 1245	-	expression tag
Glu 1246	-	expression tag
Asn 1247	-	expression tag
Leu 1248	-	expression tag
Tyr 1249	-	expression tag
Phe 1250	-	expression tag
Gln 1251	-	expression tag
Gly 1252	-	expression tag
Gly 1253	-	expression tag
Gly 1254	-	expression tag
Gly 1255	-	expression tag
Ser 1256	-	expression tag
Gly 1257	-	expression tag
Leu 1258	-	expression tag
Asn 1259	-	expression tag
Asp 1260	-	expression tag
Ile 1261	-	expression tag
Phe 1262	-	expression tag
Glu 1263	-	expression tag
Ala 1264	-	expression tag
Gln 1265	-	expression tag
Lys 1266	-	expression tag
Ile 1267	-	expression tag
Glu 1268	-	expression tag
Trp 1269	-	expression tag
His 1270	-	expression tag
Glu 1271	-	expression tag
Gly 1272	-	expression tag
His 1273	-	expression tag
His 1274	-	expression tag
His 1275	-	expression tag
His 1276	-	expression tag
His 1277	-	expression tag
His 1278	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	197487.1
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	197708.3

*Water molecules are not included.