7X6C
Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (C, A, B, D) | Short transient receptor potential channel 5 | polymer | 773 | 89951.9 | 4 | UniProt (Q9UL62) Pfam (PF12796) Pfam (PF00023) Pfam (PF08344) Pfam (PF00520) | Homo sapiens (human) | TrpC5,Transient receptor protein 5,TRP-5,hTRP-5,hTRP5 |
| 2 | E, K, R, X (C, A, B, D) | PHOSPHATIDYLETHANOLAMINE | non-polymer | 734.0 | 4 | Chemie (PTY) | |||
| 3 | F, L, S, Y (C, A, B, D) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 4 | Chemie (POV) | |||
| 4 | G, M, T, Z (C, A, B, D) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 4 | Chemie (Y01) | |||
| 5 | AA, H, N, U (D, C, A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 6 | BA, I, O, V (D, C, A, B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 7 | J, P, Q, W (C, A, B, D) | (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 594.9 | 4 | Chemie (YZY) |
Sequence modifications
C, A, B, D: 1 - 765 (UniProt: Q9UL62)
| PDB | External Database | Details |
|---|---|---|
| Ser 766 | - | expression tag |
| Arg 767 | - | expression tag |
| Leu 768 | - | expression tag |
| Glu 769 | - | expression tag |
| Val 770 | - | expression tag |
| Leu 771 | - | expression tag |
| Phe 772 | - | expression tag |
| Gln 773 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 359807.6 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 10725.1 | |
| All* | Total formula weight | 370532.7 |
