7X1R

Cryo-EM structure of human thioredoxin reductase bound by Au

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Thioredoxin reductase 1, cytoplasmic	polymer	510	56116.8	2	UniProt (Q16881) Pfam (PF07992) Pfam (PF02852) In PDB	Homo sapiens (human)	TR,Gene associated with retinoic and interferon-induced mortality 12 protein,GRIM-12,Gene associated with retinoic and IFN-induced mortality 12 protein,KM-102-derived reductase-like factor,Thioredoxin reductase TR1
2	A, B	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	2	Chemie (FAD)
3	A, B	GOLD ION	non-polymer		197.0	2	Chemie (AU)

Sequence modifications

A, B: 2 - 499 (UniProt: Q16881)

PDB	External Database	Details
Met -10	-	initiating methionine
Trp -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
Pro -6	-	expression tag
Gln -5	-	expression tag
Phe -4	-	expression tag
Glu -3	-	expression tag
Lys -2	-	expression tag
Leu -1	-	expression tag
Gly 0	-	expression tag
Ser 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	112233.7
Non-Polymers*	Number of molecules	4
	Total formula weight	1965.0
All*	Total formula weight	114198.7

*Water molecules are not included.