7X1R
Cryo-EM structure of human thioredoxin reductase bound by Au
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Thioredoxin reductase 1, cytoplasmic | polymer | 510 | 56116.8 | 2 | UniProt (Q16881) Pfam (PF07992) Pfam (PF02852) | Homo sapiens (human) | TR,Gene associated with retinoic and interferon-induced mortality 12 protein,GRIM-12,Gene associated with retinoic and IFN-induced mortality 12 protein,KM-102-derived reductase-like factor,Thioredoxin reductase TR1 |
| 2 | C, E (A, B) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 2 | Chemie (FAD) | |||
| 3 | D, F (A, B) | GOLD ION | non-polymer | 197.0 | 2 | Chemie (AU) |
Sequence modifications
A, B: 2 - 499 (UniProt: Q16881)
| PDB | External Database | Details |
|---|---|---|
| Met -10 | - | initiating methionine |
| Trp -9 | - | expression tag |
| Ser -8 | - | expression tag |
| His -7 | - | expression tag |
| Pro -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Phe -4 | - | expression tag |
| Glu -3 | - | expression tag |
| Lys -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 112233.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1965.0 | |
| All* | Total formula weight | 114198.7 |
