7X0Z

Cryo-EM structure of human ABCD1 E630Q in the presence of ATP and Magnesium in outward-facing state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	ATP-binding cassette sub-family D member 1	polymer	763	85194.1	2	UniProt (P33897) Pfam (PF06472) Pfam (PF00005)	Homo sapiens (human)	Adrenoleukodystrophy protein,ALDP
2	C, E (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
3	D, F (A, B)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)

Sequence modifications

A, B: 1 - 745 (UniProt: P33897)

PDB	External Database	Details
Met -17	-	initiating methionine
Asp -16	-	expression tag
Tyr -15	-	expression tag
Lys -14	-	expression tag
Asp -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Asp -10	-	expression tag
Lys -9	-	expression tag
Gly -8	-	expression tag
Ser -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag
Gln 630	Glu 630	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	170388.3
Non-Polymers*	Number of molecules	4
	Total formula weight	1063.0
All*	Total formula weight	171451.2

*Water molecules are not included.