7WZ3

Cryo-EM structure of human TRiC-tubulin-S1 state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (a, A)	T-complex protein 1 subunit alpha	polymer	556	60418.5	2	UniProt (P17987) Pfam (PF00118)	Homo sapiens (human)	TCP-1-alpha,CCT-alpha
2	C, D (b, B)	T-complex protein 1 subunit beta	polymer	535	57567.1	2	UniProt (P78371) Pfam (PF00118)	Homo sapiens (human)	TCP-1-beta,CCT-beta
3	E, F (D, d)	T-complex protein 1 subunit delta	polymer	539	57996.1	2	UniProt (P50991) Pfam (PF00118)	Homo sapiens (human)	TCP-1-delta,CCT-delta,Stimulator of TAR RNA-binding
4	G, H (E, e)	T-complex protein 1 subunit epsilon	polymer	539	59547.7	2	UniProt (P48643) Pfam (PF00118)	Homo sapiens (human)	TCP-1-epsilon,CCT-epsilon
5	I, J (g, G)	T-complex protein 1 subunit gamma	polymer	545	60613.9	2	UniProt (P49368) Pfam (PF00118)	Homo sapiens (human)	TCP-1-gamma,CCT-gamma,hTRiC5
6	K, L (h, H)	T-complex protein 1 subunit eta	polymer	543	59417.5	2	UniProt (Q99832) Pfam (PF00118)	Homo sapiens (human)	TCP-1-eta,CCT-eta,HIV-1 Nef-interacting protein
7	M, N (Q, q)	T-complex protein 1 subunit theta	polymer	548	59691.4	2	UniProt (P50990) Pfam (PF00118)	Homo sapiens (human)	TCP-1-theta,CCT-theta,Chaperonin containing T-complex polypeptide 1 subunit 8,Renal carcinoma antigen NY-REN-15
8	O, P (Z, z)	T-complex protein 1 subunit zeta	polymer	531	58106.1	2	UniProt (P40227) Pfam (PF00118)	Homo sapiens (human)	TCP-1-zeta,Acute morphine dependence-related protein 2,CCT-zeta-1,HTR3,Tcp20
9	Q, R, S, T, U... (g, G, Q, q, Z...)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	6	Chemie (ADP)

Sequence modifications

h, H: 1 - 543 (UniProt: Q99832)

PDB	External Database	Details
Ser 290	Leu 290	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	946716.5
Non-Polymers*	Number of molecules	6
	Total formula weight	2563.2
All*	Total formula weight	949279.7

*Water molecules are not included.