7WYL
Structure of the EV71 3Cpro with 337 inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 3C protein | polymer | 187 | 20521.5 | 2 | UniProt (E7E815) Pfam (PF00548) | Enterovirus A71 | Protein 3B,Viral protein genome-linked |
| 2 | C (A) | N-methyl-N-[[4-(trifluoromethyl)-1,3-thiazol-2-yl]methyl]prop-2-enamide | non-polymer | 250.2 | 1 | Chemie (G7L) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 390 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 183 (UniProt: E7E815)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
| Gly 133 | His 133 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 41043.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 250.2 | |
| All* | Total formula weight | 41293.3 |
