7WVE
CT-mut (D523K,D524K,E527K) TLR3-poly(I:C) complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Toll-like receptor 3 | polymer | 680 | 77539.6 | 2 | UniProt (O15455) Pfam (PF13855) Pfam (PF13516) Pfam (PF00560) | Homo sapiens (human) | |
| 2 | C (E) | RNA (46-MER) | polymer | 46 | 13993.4 | 1 | synthetic construct | ||
| 3 | D (F) | RNA (46-MER) | polymer | 46 | 15143.8 | 1 | synthetic construct |
Sequence modifications
A, B: 27 - 697 (UniProt: O15455)
| PDB | External Database | Details |
|---|---|---|
| Ala 24 | - | expression tag |
| Asp 25 | - | expression tag |
| Pro 26 | - | expression tag |
| Lys 523 | Asp 523 | engineered mutation |
| Lys 524 | Asp 524 | engineered mutation |
| Lys 527 | Glu 527 | engineered mutation |
| His 698 | - | expression tag |
| His 699 | - | expression tag |
| His 700 | - | expression tag |
| His 701 | - | expression tag |
| His 702 | - | expression tag |
| His 703 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 184216.4 | |
| All* | Total formula weight | 184216.4 |
