7WUJ
Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | mini-Gs | polymer | 361 | 41879.5 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P63096) UniProt (by SIFTS) (P63092) | Homo sapiens (human) | |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 358 | 39489.2 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (E) | Adhesion G-protein coupled receptor G4,Uncharacterized protein | polymer | 631 | 71628.0 | 1 | UniProt (Q8IZF6) UniProt (A0A366VY15) Pfam (PF00002) | Homo sapiens (human) | G-protein coupled receptor 112 |
| 4 | D (S) | scFv16 | polymer | 250 | 26610.6 | 1 | synthetic construct | ||
| 5 | E (Y) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 6 | F (N) | Nanobody-35 | polymer | 128 | 13885.4 | 1 | Lama glama |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
E: 2720 - 3080 (UniProt: Q8IZF6)
E: 3099 - 3334 (UniProt: A0A366VY15)
| PDB | External Database | Details |
|---|---|---|
| Met -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Leu -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Val -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gln 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 2704 | - | expression tag |
| Lys 2705 | - | expression tag |
| Thr 2706 | - | expression tag |
| Ile 2707 | - | expression tag |
| Ile 2708 | - | expression tag |
| Ala 2709 | - | expression tag |
| Leu 2710 | - | expression tag |
| Ser 2711 | - | expression tag |
| Tyr 2712 | - | expression tag |
| Ile 2713 | - | expression tag |
| Phe 2714 | - | expression tag |
| Cys 2715 | - | expression tag |
| Leu 2716 | - | expression tag |
| Val 2717 | - | expression tag |
| Phe 2718 | - | expression tag |
| Ala 2719 | - | expression tag |
| His 3081 | - | linker |
| His 3082 | - | linker |
| His 3083 | - | linker |
| His 3084 | - | linker |
| His 3085 | - | linker |
| His 3086 | - | linker |
| His 3087 | - | linker |
| His 3088 | - | linker |
| Gly 3089 | - | linker |
| Ser 3090 | - | linker |
| Ala 3091 | - | linker |
| Glu 3092 | - | linker |
| Asn 3093 | - | linker |
| Leu 3094 | - | linker |
| Tyr 3095 | - | linker |
| Phe 3096 | - | linker |
| Gln 3097 | - | linker |
| Gly 3098 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 201353.8 | |
| All* | Total formula weight | 201353.8 |
