7WUI
Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | mini-Gs | polymer | 361 | 41879.5 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P63092) UniProt (by SIFTS) (P63096) | Homo sapiens (human) | |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 358 | 39489.2 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 58 | 6375.3 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (N) | Nanobody-35 | polymer | 128 | 13885.4 | 1 | Lama glama | ||
| 5 | E (R) | Adhesion G-protein coupled receptor G2,mCherry | polymer | 1149 | 126852.2 | 1 | UniProt (Q8CJ12) Pfam (PF01825) Pfam (PF00002) | Mus musculus (house mouse) | G-protein coupled receptor 64,Mouse epididymis-specific protein 6,Me6 |
| 6 | F (S) | scFv16 | polymer | 250 | 26610.6 | 1 | synthetic construct | ||
| 7 | G (L) | IP15 | polymer | 15 | 1646.9 | 1 | UniProt (by SIFTS) (Q8CJ12) | synthetic construct |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
R: 38 - 891 (UniProt: Q8CJ12)
R: 935 - 1170 (PDB: 7WUI)
| PDB | External Database | Details |
|---|---|---|
| Met -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Leu -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Val -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gln 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 22 | - | expression tag |
| Lys 23 | - | expression tag |
| Thr 24 | - | expression tag |
| Ile 25 | - | expression tag |
| Ile 26 | - | expression tag |
| Ala 27 | - | expression tag |
| Leu 28 | - | expression tag |
| Ser 29 | - | expression tag |
| Tyr 30 | - | expression tag |
| Ile 31 | - | expression tag |
| Phe 32 | - | expression tag |
| Cys 33 | - | expression tag |
| Leu 34 | - | expression tag |
| Val 35 | - | expression tag |
| Phe 36 | - | expression tag |
| Ala 37 | - | expression tag |
| Ala 597 | His 597 | engineered mutation |
| Ala 599 | Thr 599 | engineered mutation |
| Phe 892 | - | linker |
| Trp 893 | - | linker |
| Phe 894 | - | linker |
| Pro 895 | - | linker |
| Glu 896 | - | linker |
| Lys 897 | - | linker |
| Gly 898 | - | linker |
| Ala 899 | - | linker |
| Ile 900 | - | linker |
| Leu 901 | - | linker |
| Thr 902 | - | linker |
| Asp 903 | - | linker |
| Thr 904 | - | linker |
| Ser 905 | - | linker |
| Val 906 | - | linker |
| Lys 907 | - | linker |
| Arg 908 | - | linker |
| Asn 909 | - | linker |
| Asp 910 | - | linker |
| Leu 911 | - | linker |
| Ser 912 | - | linker |
| Ile 913 | - | linker |
| Ile 914 | - | linker |
| Ser 915 | - | linker |
| Gly 916 | - | linker |
| His 917 | - | linker |
| His 918 | - | linker |
| His 919 | - | linker |
| His 920 | - | linker |
| His 921 | - | linker |
| His 922 | - | linker |
| His 923 | - | linker |
| His 924 | - | linker |
| Gly 925 | - | linker |
| Ser 926 | - | linker |
| Ala 927 | - | linker |
| Glu 928 | - | linker |
| Asn 929 | - | linker |
| Leu 930 | - | linker |
| Tyr 931 | - | linker |
| Phe 932 | - | linker |
| Gln 933 | - | linker |
| Gly 934 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 256739.2 | |
| All* | Total formula weight | 256739.2 |
