7WUI
Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | mini-Gs | polymer | 361 | 41879.5 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P63092) UniProt (by SIFTS) (P63096) In PDB | Homo sapiens (human) | |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 358 | 39489.2 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 58 | 6375.3 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | N | Nanobody-35 | polymer | 128 | 13885.4 | 1 | Lama glama | ||
5 | R | Adhesion G-protein coupled receptor G2,mCherry | polymer | 1149 | 126852.2 | 1 | UniProt (Q8CJ12) Pfam (PF01825) Pfam (PF00002) In PDB | Mus musculus (house mouse) | G-protein coupled receptor 64,Mouse epididymis-specific protein 6,Me6 |
6 | S | scFv16 | polymer | 250 | 26610.6 | 1 | synthetic construct | ||
7 | L | IP15 | polymer | 15 | 1646.9 | 1 | UniProt (by SIFTS) (Q8CJ12) In PDB | synthetic construct |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
R: 38 - 891 (UniProt: Q8CJ12)
R: 935 - 1170 (PDB: 7WUI)
PDB | External Database | Details |
---|---|---|
Met -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Leu -10 | - | expression tag |
Glu -9 | - | expression tag |
Val -8 | - | expression tag |
Leu -7 | - | expression tag |
Phe -6 | - | expression tag |
Gln -5 | - | expression tag |
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gln 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 22 | - | expression tag |
Lys 23 | - | expression tag |
Thr 24 | - | expression tag |
Ile 25 | - | expression tag |
Ile 26 | - | expression tag |
Ala 27 | - | expression tag |
Leu 28 | - | expression tag |
Ser 29 | - | expression tag |
Tyr 30 | - | expression tag |
Ile 31 | - | expression tag |
Phe 32 | - | expression tag |
Cys 33 | - | expression tag |
Leu 34 | - | expression tag |
Val 35 | - | expression tag |
Phe 36 | - | expression tag |
Ala 37 | - | expression tag |
Ala 597 | His 597 | engineered mutation |
Ala 599 | Thr 599 | engineered mutation |
Phe 892 | - | linker |
Trp 893 | - | linker |
Phe 894 | - | linker |
Pro 895 | - | linker |
Glu 896 | - | linker |
Lys 897 | - | linker |
Gly 898 | - | linker |
Ala 899 | - | linker |
Ile 900 | - | linker |
Leu 901 | - | linker |
Thr 902 | - | linker |
Asp 903 | - | linker |
Thr 904 | - | linker |
Ser 905 | - | linker |
Val 906 | - | linker |
Lys 907 | - | linker |
Arg 908 | - | linker |
Asn 909 | - | linker |
Asp 910 | - | linker |
Leu 911 | - | linker |
Ser 912 | - | linker |
Ile 913 | - | linker |
Ile 914 | - | linker |
Ser 915 | - | linker |
Gly 916 | - | linker |
His 917 | - | linker |
His 918 | - | linker |
His 919 | - | linker |
His 920 | - | linker |
His 921 | - | linker |
His 922 | - | linker |
His 923 | - | linker |
His 924 | - | linker |
Gly 925 | - | linker |
Ser 926 | - | linker |
Ala 927 | - | linker |
Glu 928 | - | linker |
Asn 929 | - | linker |
Leu 930 | - | linker |
Tyr 931 | - | linker |
Phe 932 | - | linker |
Gln 933 | - | linker |
Gly 934 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 7 |
Total formula weight | 256739.2 | |
All* | Total formula weight | 256739.2 |