7WQQ

Retinoic acid receptor alpha mutant - N299H

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Retinoic acid receptor alpha	polymer	265	30150.8	1	UniProt (P10276) Pfam (PF00104)	Homo sapiens (human)	RAR-alpha,Nuclear receptor subfamily 1 group B member 1
2	B (C)	Peptide from Nuclear receptor coactivator 1	polymer	13	1591.9	1	UniProt (Q15788)	Homo sapiens
3	C (A)	4-[(E)-3-(3,5-ditert-butylphenyl)-3-oxidanylidene-prop-1-enyl]benzoic acid	non-polymer		364.5	1	Chemie (5Z6)
4	D, E (A, C)	water	water		18.0	142	Chemie (HOH)

Sequence modifications

A: 176 - 421 (UniProt: P10276)

PDB	External Database	Details
Met 157	-	initiating methionine
Lys 158	-	expression tag
Ser 159	-	expression tag
Ser 160	-	expression tag
His 161	-	expression tag
His 162	-	expression tag
His 163	-	expression tag
His 164	-	expression tag
His 165	-	expression tag
His 166	-	expression tag
Glu 167	-	expression tag
Asn 168	-	expression tag
Leu 169	-	expression tag
Tyr 170	-	expression tag
Phe 171	-	expression tag
Gln 172	-	expression tag
Ser 173	-	expression tag
Asn 174	-	expression tag
Ala 175	-	expression tag
His 299	Asn 299	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	31742.7
Non-Polymers*	Number of molecules	1
	Total formula weight	364.5
All*	Total formula weight	32107.1

*Water molecules are not included.