7WPI
Methionyl-tRNA synthetase from Staphylococcus aureus complexed with a phenylbenzimidazole inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Methionine--tRNA ligase | polymer | 530 | 61104.0 | 1 | UniProt (Q5HII6) Pfam (PF09334) Pfam (PF08264) | Staphylococcus aureus | Methionyl-tRNA synthetase,MetRS |
| 2 | B (A) | 2-(4-bromanyl-3-oxidanyl-phenyl)-1-[(1R)-2-[2-(2-tert-butylphenoxy)ethanoylamino]-1-(3,4-dimethoxyphenyl)ethyl]-N-methyl-benzimidazole-5-carboxamide | non-polymer | 715.6 | 1 | Chemie (1V7) | |||
| 3 | C (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 4 | D, E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 5 | F (A) | water | water | 18.0 | 68 | Chemie (HOH) |
Sequence modifications
A: 2 - 520 (UniProt: Q5HII6)
| PDB | External Database | Details |
|---|---|---|
| Met -9 | - | initiating methionine |
| Gly -8 | - | expression tag |
| Ser -7 | - | expression tag |
| Ser -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| Ser 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 61104.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 898.8 | |
| All* | Total formula weight | 62002.8 |
