7WPC

The second RBD of SARS-CoV-2 Omicron Variant in complexed with RBD-ACE2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Spike glycoprotein	polymer	1205	133912.0	2	UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB	Severe acute respiratory syndrome coronavirus 2	S glycoprotein,E2,Peplomer protein
2	D	Angiotensin-converting enzyme 2	polymer	805	92556.7	1	UniProt (Q9BYF1) Pfam (PF01401) Pfam (PF16959) In PDB	Homo sapiens (human)	Angiotensin-converting enzyme homolog,ACEH,Angiotensin-converting enzyme-related carboxypeptidase,ACE-related carboxypeptidase,Metalloprotease MPROT15
3	C, E	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	D	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
5	D	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
6	D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)

Sequence modifications

A, B: 1 - 1205 (UniProt: P0DTC2)

PDB	External Database	Details
Val 67	Ala 67	variant
-	His 69	deletion
-	Val 70	deletion
Ile 93	Thr 95	variant
Asp 140	Gly 142	variant
-	Val 143	deletion
-	Tyr 144	deletion
-	Tyr 145	deletion
-	Asn 211	deletion
Ile 206	Leu 212	variant
Glu 209	-	insertion
Pro 210	-	insertion
Glu 211	-	insertion
Asp 336	Gly 339	variant
Leu 368	Ser 371	variant
Pro 370	Ser 373	variant
Phe 372	Ser 375	variant
Asn 414	Lys 417	variant
Lys 437	Asn 440	variant
Ser 443	Gly 446	variant
Asn 474	Ser 477	variant
Lys 475	Thr 478	variant
Ala 481	Glu 484	variant
Arg 490	Gln 493	variant
Ser 493	Gly 496	variant
Arg 495	Gln 498	variant
Tyr 498	Asn 501	variant
His 502	Tyr 505	variant
Lys 544	Thr 547	variant
Gly 611	Asp 614	variant
Tyr 652	His 655	variant
Lys 676	Asn 679	variant
His 678	Pro 681	variant
Gly 679	Arg 682	engineered mutation
Ser 680	Arg 683	engineered mutation
Ser 682	Arg 685	engineered mutation
Lys 761	Asn 764	variant
Tyr 793	Asp 796	variant
Lys 853	Asn 856	variant
His 951	Gln 954	variant
Lys 966	Asn 969	variant
Phe 978	Leu 981	variant
Pro 983	Lys 986	engineered mutation
Pro 984	Val 987	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	360380.6
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	5
	Total formula weight	764.5
All*	Total formula weight	361993.9

*Water molecules are not included.