7WNV
Crystal structure of mutant estrogen receptor alpha Y537S in complex with CO9
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Estrogen receptor | polymer | 259 | 29501.7 | 4 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | A, B, C, D | (~{Z})-4-[2-[4-[[2-(4-hydroxyphenyl)-6-oxidanyl-1-benzothiophen-3-yl]oxy]phenoxy]ethylamino]-~{N},~{N}-dimethyl-but-2-enamide | non-polymer | 504.6 | 4 | Chemie (2I9) | |||
| 3 | water | water | 18.0 | 85 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 297 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 296 | - | expression tag |
| Ser 417 | Cys 417 | engineered mutation |
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 118007.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2018.4 | |
| All* | Total formula weight | 120025.3 |
