7WNI
Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor Y13158
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Isoform 4 of Bromodomain-containing protein 2 | polymer | 136 | 15981.2 | 2 | UniProt (P25440) Pfam (PF00439) In PDB | Homo sapiens (human) | O27.1.1,Really interesting new gene 3 protein |
2 | A, B | 7-[2-[2,4-bis(fluoranyl)phenoxy]-5-(2-oxidanylpropan-2-yl)phenyl]-2-[4-(2-hydroxyethyloxy)-3,5-dimethyl-phenyl]-5-methyl-furo[3,2-c]pyridin-4-one | non-polymer | 575.6 | 2 | Chemie (JGU) | |||
3 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
4 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
5 | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A, B: 344 - 455 (UniProt: P25440)
PDB | External Database | Details |
---|---|---|
Glu 320 | - | expression tag |
Gly 321 | - | expression tag |
Asp 322 | - | expression tag |
Ile 323 | - | expression tag |
His 324 | - | expression tag |
Met 325 | - | expression tag |
Lys 326 | - | expression tag |
Lys 327 | - | expression tag |
Gly 328 | - | expression tag |
His 329 | - | expression tag |
His 330 | - | expression tag |
His 331 | - | expression tag |
His 332 | - | expression tag |
His 333 | - | expression tag |
His 334 | - | expression tag |
Glu 335 | - | expression tag |
Asn 336 | - | expression tag |
Leu 337 | - | expression tag |
Tyr 338 | - | expression tag |
Phe 339 | - | expression tag |
Gln 340 | - | expression tag |
Gly 341 | - | expression tag |
Gly 342 | - | expression tag |
Ser 343 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 31962.4 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1505.6 | |
All* | Total formula weight | 33468.0 |