7WN3
Cryo-EM structure of VWF D'D3 dimer (2M mutant) complexed with D1D2 at 3.29 angstron resolution (2 units)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, F (A, B, E, G) | von Willebrand antigen 2 | polymer | 741 | 81427.7 | 4 | UniProt (P04275) Pfam (PF00094) Pfam (PF08742) Pfam (PF01826) | Homo sapiens (human) | von Willebrand antigen II |
| 2 | B, D, G, H (F, H, C, D) | von Willebrand factor | polymer | 490 | 54208.9 | 4 | UniProt (P04275) Pfam (PF25962) Pfam (PF16164) Pfam (PF23244) Pfam (PF00094) Pfam (PF08742) | Homo sapiens (human) | vWF |
| 3 | AA, BA, EA, FA, I... (E, G, A, C, F...) | CALCIUM ION | non-polymer | 40.1 | 16 | Chemie (CA) | |||
| 4 | CA, DA, GA, HA, IA... (E, G, C, A, F...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 20 | Chemie (NAG) |
Sequence modifications
F, H, C, D: 764 - 1241 (UniProt: P04275)
| PDB | External Database | Details |
|---|---|---|
| Met 1136 | Arg 1136 | engineered mutation |
| Met 1143 | Glu 1143 | engineered mutation |
| Gly 1242 | - | expression tag |
| Leu 1243 | - | expression tag |
| Val 1244 | - | expression tag |
| Val 1245 | - | expression tag |
| Pro 1246 | - | expression tag |
| Pro 1247 | - | expression tag |
| His 1248 | - | expression tag |
| His 1249 | - | expression tag |
| His 1250 | - | expression tag |
| His 1251 | - | expression tag |
| His 1252 | - | expression tag |
| His 1253 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 542546.4 | |
| Non-Polymers* | Number of molecules | 36 |
| Total formula weight | 5065.4 | |
| All* | Total formula weight | 547611.8 |
