7WMU
Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor Y13146
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Isoform 4 of Bromodomain-containing protein 2 | polymer | 136 | 15981.2 | 1 | UniProt (P25440) Pfam (PF00439) In PDB | Homo sapiens (human) | O27.1.1,Really interesting new gene 3 protein |
2 | A | ~{N}-[4-[2,4-bis(fluoranyl)phenoxy]-3-[2-(2-cyclobutyl-1~{H}-imidazol-5-yl)-5-methyl-4-oxidanylidene-furo[3,2-c]pyridin-7-yl]phenyl]ethanesulfonamide | non-polymer | 580.6 | 1 | Chemie (JGF) | |||
3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
4 | water | water | 18.0 | 112 | Chemie (HOH) |
Sequence modifications
A: 344 - 455 (UniProt: P25440)
PDB | External Database | Details |
---|---|---|
Glu 320 | - | expression tag |
Gly 321 | - | expression tag |
Asp 322 | - | expression tag |
Ile 323 | - | expression tag |
His 324 | - | expression tag |
Met 325 | - | expression tag |
Lys 326 | - | expression tag |
Lys 327 | - | expression tag |
Gly 328 | - | expression tag |
His 329 | - | expression tag |
His 330 | - | expression tag |
His 331 | - | expression tag |
His 332 | - | expression tag |
His 333 | - | expression tag |
His 334 | - | expression tag |
Glu 335 | - | expression tag |
Asn 336 | - | expression tag |
Leu 337 | - | expression tag |
Tyr 338 | - | expression tag |
Phe 339 | - | expression tag |
Gln 340 | - | expression tag |
Gly 341 | - | expression tag |
Gly 342 | - | expression tag |
Ser 343 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 15981.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 642.7 | |
All* | Total formula weight | 16623.9 |