7WMQ
Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor Y13157
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Isoform 4 of Bromodomain-containing protein 2 | polymer | 136 | 15981.2 | 4 | UniProt (P25440) Pfam (PF00439) In PDB | Homo sapiens (human) | O27.1.1,Really interesting new gene 3 protein |
2 | A, B, C, D | 2-(2-cyclobutyl-1~{H}-imidazol-5-yl)-7-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-5-methyl-furo[3,2-c]pyridin-4-one | non-polymer | 541.6 | 4 | Chemie (JFL) | |||
3 | D, A, B, C | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
4 | D, A, B, C | FORMIC ACID | non-polymer | 46.0 | 15 | Chemie (FMT) | |||
5 | water | water | 18.0 | 210 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 344 - 455 (UniProt: P25440)
PDB | External Database | Details |
---|---|---|
Glu 320 | - | expression tag |
Gly 321 | - | expression tag |
Asp 322 | - | expression tag |
Ile 323 | - | expression tag |
His 324 | - | expression tag |
Met 325 | - | expression tag |
Lys 326 | - | expression tag |
Lys 327 | - | expression tag |
Gly 328 | - | expression tag |
His 329 | - | expression tag |
His 330 | - | expression tag |
His 331 | - | expression tag |
His 332 | - | expression tag |
His 333 | - | expression tag |
His 334 | - | expression tag |
Glu 335 | - | expression tag |
Asn 336 | - | expression tag |
Leu 337 | - | expression tag |
Tyr 338 | - | expression tag |
Phe 339 | - | expression tag |
Gln 340 | - | expression tag |
Gly 341 | - | expression tag |
Gly 342 | - | expression tag |
Ser 343 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 63924.9 | |
Non-Polymers* | Number of molecules | 25 |
Total formula weight | 3409.4 | |
All* | Total formula weight | 67334.3 |