7WJS
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor Y13157
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Bromodomain-containing protein 4 | polymer | 141 | 16767.3 | 3 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (human) | Protein HUNK1 |
2 | A, B, C | 2-(2-cyclobutyl-1~{H}-imidazol-5-yl)-7-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-5-methyl-furo[3,2-c]pyridin-4-one | non-polymer | 541.6 | 3 | Chemie (JFL) | |||
3 | A, B, C | GLYCEROL | non-polymer | 92.1 | 9 | Chemie (GOL) | |||
4 | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
A, B, C: 44 - 168 (UniProt: O60885)
PDB | External Database | Details |
---|---|---|
Met 28 | - | expression tag |
Lys 29 | - | expression tag |
Lys 30 | - | expression tag |
Gly 31 | - | expression tag |
His 32 | - | expression tag |
His 33 | - | expression tag |
His 34 | - | expression tag |
His 35 | - | expression tag |
His 36 | - | expression tag |
His 37 | - | expression tag |
Leu 38 | - | expression tag |
Val 39 | - | expression tag |
Pro 40 | - | expression tag |
Arg 41 | - | expression tag |
Gly 42 | - | expression tag |
Ser 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 50302.0 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 2453.7 | |
All* | Total formula weight | 52755.7 |