7WG3
Structural basis of interleukin-17B receptor in complex with a neutralizing antibody D9 for guiding humanization and affinity maturation for cancer therapy
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Light chain of D9 Fab | polymer | 213 | 23269.8 | 4 | Mus musculus | ||
| 2 | E, F, G, H (E, F, G, H) | Heavy chain of D9 Fab | polymer | 220 | 23499.1 | 4 | Mus musculus | ||
| 3 | I, J, K, L (I, J, K, L) | IL17RB protein | polymer | 255 | 28176.1 | 4 | UniProt (A3KN55) Pfam (PF16556) Pfam (PF16578) | Bos taurus (cattle) | Interleukin 17 receptor B |
| 4 | M (M) | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G34442SS) | |||
| 5 | N (N) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 6 | AA, BA, CA, DA, EA... (K, L, I, J) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 18 | Chemie (NAG) | |||
| 7 | GA, HA, IA, JA, KA... (A, B, C, D, E...) | water | water | 18.0 | 1039 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 299780.0 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1983.8 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 3981.7 | |
| All* | Total formula weight | 305745.6 |
