7WCV

Co-crystal structure of FTO bound to 6e

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Alpha-ketoglutarate-dependent dioxygenase FTO	polymer	491	56460.6	1	UniProt (Q9C0B1) Pfam (PF12933) Pfam (PF12934) In PDB	Homo sapiens (human)	Fat mass and obesity-associated protein,U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO,U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO,mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO,m6A(m)-demethylase FTO,mRNA N(6)-methyladenosine demethylase FTO,tRNA N1-methyl adenine demethylase FTO
2	A	2-OXOGLUTARIC ACID	non-polymer		146.1	1	Chemie (AKG)
3	A	MANGANESE (II) ION	non-polymer		54.9	1	Chemie (MN)
4	A	2-[[2,6-bis(chloranyl)-4-pyridin-4-yl-phenyl]amino]benzoic acid	non-polymer		359.2	1	Chemie (943)
5		water	water		18.0	26	Chemie (HOH)

Sequence modifications

A: 32 - 505 (UniProt: Q9C0B1)

PDB	External Database	Details
His 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
His 18	-	expression tag
His 19	-	expression tag
His 20	-	expression tag
Ser 21	-	expression tag
Ser 22	-	expression tag
Gly 23	-	expression tag
Leu 24	-	expression tag
Val 25	-	expression tag
Pro 26	-	expression tag
Arg 27	-	expression tag
Gly 28	-	expression tag
Ser 29	-	expression tag
His 30	-	expression tag
Met 31	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	56460.6
Non-Polymers*	Number of molecules	3
	Total formula weight	560.2
All*	Total formula weight	57020.9

*Water molecules are not included.