7WC8
Crystal structure of serotonin 2A receptor in complex with lumateperone
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | 5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,Soluble cytochrome b562 | polymer | 376 | 42056.3 | 1 | UniProt (P28223) Pfam (PF00001) Pfam (PF07361) UniProt (by SIFTS) (P0ABE7) In PDB | Homo sapiens (human) | 5-HT-2,5-HT-2A,Serotonin receptor 2A |
2 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
3 | A | CHOLESTEROL | non-polymer | 386.7 | 4 | Chemie (CLR) | |||
4 | A | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
5 | A | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 11 | Chemie (OLC) | |||
6 | A | 1-(4-fluorophenyl)-4-[(10~{R},15~{S})-4-methyl-1,4,12-triazatetracyclo[7.6.1.0^{5,16}.0^{10,15}]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one | non-polymer | 393.5 | 1 | Chemie (92S) | |||
7 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
8 | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 67 - 265 (UniProt: P28223)
A: 1001 - 1106 (PDB: 7WC8)
A: 313 - 403 (UniProt: P28223)
PDB | External Database | Details |
---|---|---|
Lys 162 | Ser 162 | engineered mutation |
Trp 164 | Met 164 | engineered mutation |
A: 313 - 403 (UniProt: P28223)
PDB | External Database | Details |
---|---|---|
Asn 372 | Ser 372 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 42056.3 | |
Non-Polymers* | Number of molecules | 19 |
Total formula weight | 6230.8 | |
All* | Total formula weight | 48287.0 |