7WC7
Crystal structure of serotonin 2A receptor in complex with lisuride
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | 5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,Soluble cytochrome b562 | polymer | 376 | 42056.3 | 1 | UniProt (P28223) Pfam (PF00001) Pfam (PF07361) UniProt (by SIFTS) (P0ABE7) In PDB | Homo sapiens (human) | 5-HT-2,5-HT-2A,Serotonin receptor 2A |
| 2 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 3 | A | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 4 | A | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
| 5 | A | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 5 | Chemie (OLC) | |||
| 6 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 3 | Chemie (PEG) | |||
| 7 | A | N,N-diethyl-N'-[(8alpha)-6-methyl-9,10-didehydroergolin-8-yl]urea | non-polymer | 338.4 | 1 | Chemie (H8G) | |||
| 8 | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
A: 67 - 265 (UniProt: P28223)
A: 1001 - 1106 (PDB: 7WC7)
A: 313 - 403 (UniProt: P28223)
| PDB | External Database | Details |
|---|---|---|
| Lys 162 | Ser 162 | engineered mutation |
| Trp 164 | Met 164 | engineered mutation |
A: 313 - 403 (UniProt: P28223)
| PDB | External Database | Details |
|---|---|---|
| Asn 372 | Ser 372 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42056.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3088.7 | |
| All* | Total formula weight | 45145.0 |
