7W9V
Cryo-EM structure of nucleosome in complex with p300 acetyltransferase catalytic core (complex I)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, E | Histone H3.1 | polymer | 135 | 15306.0 | 2 | UniProt (P68431) Pfam (PF00125) In PDB | Homo sapiens (human) | Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l |
2 | B, F | Histone H4 | polymer | 106 | 11676.7 | 2 | UniProt (P62805) Pfam (PF15511) In PDB | Homo sapiens (human) | |
3 | C, G | Histone H2A type 1-B/E | polymer | 133 | 14447.8 | 2 | UniProt (P04908) Pfam (PF00125) Pfam (PF16211) In PDB | Homo sapiens (human) | Histone H2A.2,Histone H2A/a,Histone H2A/m |
4 | D, H | Histone H2B type 1-J | polymer | 129 | 14217.5 | 2 | UniProt (P06899) Pfam (PF00125) In PDB | Homo sapiens (human) | Histone H2B.1,Histone H2B.r,H2B/r |
5 | I | DNA (145-MER) | polymer | 145 | 44520.4 | 1 | synthetic construct | ||
6 | J | DNA (145-MER) | polymer | 145 | 44991.7 | 1 | synthetic construct | ||
7 | K | Histone acetyltransferase p300 | polymer | 638 | 74426.6 | 1 | UniProt (Q09472) Pfam (PF00439) Pfam (PF06001) Pfam (PF08214) Pfam (PF00569) In PDB | Homo sapiens (human) | p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein 2-hydroxyisobutyryltransferase p300,Protein lactyltransferas p300,Protein propionyltransferase p300 |
Sequence modifications
B, F: 0 - 102 (UniProt: P62805)
C, G: 0 - 129 (UniProt: P04908)
D, H: 0 - 125 (UniProt: P06899)
K: 1035 - 1519 (UniProt: Q09472)
K: 1581 - 1720 (UniProt: Q09472)
PDB | External Database | Details |
---|---|---|
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
His -1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
His -1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
His -1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Phe 1467 | Tyr 1467 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ser 1520 | - | linker |
Gly 1521 | - | linker |
Gly 1522 | - | linker |
Ser 1523 | - | linker |
Gly 1580 | - | linker |
His 1721 | - | expression tag |
His 1722 | - | expression tag |
His 1723 | - | expression tag |
His 1724 | - | expression tag |
His 1725 | - | expression tag |
His 1726 | - | expression tag |
His 1727 | - | expression tag |
His 1728 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 11 |
Total formula weight | 275234.6 | |
All* | Total formula weight | 275234.6 |