7W6J
The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me2 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Set1/Ash2 histone methyltransferase complex subunit ASH2 | polymer | 184 | 20597.4 | 1 | UniProt (Q9UBL3) Pfam (PF00622) | Homo sapiens (human) | ASH2-like protein |
| 2 | B (C) | Histone-lysine N-methyltransferase 2A | polymer | 159 | 18314.2 | 1 | UniProt (Q03164) Pfam (PF00856) | Homo sapiens (human) | |
| 3 | C (F) | Retinoblastoma-binding protein 5 | polymer | 27 | 3255.3 | 1 | UniProt (Q15291) | Homo sapiens (human) | RBBP-5,Retinoblastoma-binding protein RBQ-3 |
| 4 | D (B) | Histone H3.3C | polymer | 9 | 1090.3 | 1 | UniProt (Q6NXT2) | Homo sapiens | Histone H3.5 |
| 5 | E (C) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 6 | F (C) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 7 | G, H, I (A, C, F) | water | water | 18.0 | 38 | Chemie (HOH) |
Sequence modifications
A: 286 - 438 (UniProt: Q9UBL3)
A: 445 - 504 (UniProt: Q9UBL3)
C: 3813 - 3970 (UniProt: Q03164)
| PDB | External Database | Details |
|---|---|---|
| Ser 285 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ile 439 | - | linker |
| Ser 440 | - | linker |
| Gly 441 | - | linker |
| Arg 442 | - | linker |
| Gly 443 | - | linker |
| Ser 444 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ser 3812 | - | expression tag |
| Ile 3861 | Asn 3861 | engineered mutation |
| Leu 3867 | Gln 3867 | engineered mutation |
| Ser 3882 | - | insertion |
| Ser 3883 | Cys 3882 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 43257.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 449.8 | |
| All* | Total formula weight | 43707.0 |
