7W6J
The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me2 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Set1/Ash2 histone methyltransferase complex subunit ASH2 | polymer | 184 | 20597.4 | 1 | UniProt (Q9UBL3) Pfam (PF00622) | Homo sapiens (human) | ASH2-like protein |
| 2 | B (C) | Histone-lysine N-methyltransferase 2A | polymer | 159 | 18314.2 | 1 | UniProt (Q03164) Pfam (PF00856) | Homo sapiens (human) | |
| 3 | C (F) | Retinoblastoma-binding protein 5 | polymer | 27 | 3255.3 | 1 | UniProt (Q15291) | Homo sapiens (human) | RBBP-5,Retinoblastoma-binding protein RBQ-3 |
| 4 | D (B) | Histone H3.3C | polymer | 9 | 1090.3 | 1 | UniProt (Q6NXT2) | Homo sapiens | Histone H3.5 |
| 5 | E (C) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (71170554) PubChem (13231890) PubChem (16760024) PubChem (25210495) PubChem (44361184) PubChem (177678424) PubChem (46936206) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (6419189) PubChem (57544532) PubChem (59046843) PubChem (59170628) PubChem (164157219) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) | |||
| 6 | F (C) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 7 | G, H, I (A, C, F) | water | water | 18.0 | 38 | Chemie (HOH) |
Sequence modifications
A: 286 - 438 (UniProt: Q9UBL3)
A: 445 - 504 (UniProt: Q9UBL3)
C: 3813 - 3970 (UniProt: Q03164)
| PDB | External Database | Details |
|---|---|---|
| Ser 285 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ile 439 | - | linker |
| Ser 440 | - | linker |
| Gly 441 | - | linker |
| Arg 442 | - | linker |
| Gly 443 | - | linker |
| Ser 444 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ser 3812 | - | expression tag |
| Ile 3861 | Asn 3861 | engineered mutation |
| Leu 3867 | Gln 3867 | engineered mutation |
| Ser 3882 | - | insertion |
| Ser 3883 | Cys 3882 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 43257.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 449.8 | |
| All* | Total formula weight | 43707.0 |
