7W57
Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 2-Gq protein complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(q) subunit alpha | polymer | 361 | 41724.4 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P63092) UniProt (by SIFTS) (P63096) | Homo sapiens | |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37915.5 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (C) | Neuromedin-S | polymer | 34 | 3927.5 | 1 | UniProt (Q5H8A3) | Homo sapiens (human) | |
| 4 | D (E) | scFv16 | polymer | 248 | 26496.5 | 1 | Homo sapiens | ||
| 5 | E (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 70 | 7729.9 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 6 | F (R) | Neuromedin-U receptor 2 | polymer | 571 | 65417.4 | 1 | Pfam (PF07361) Pfam (PF00001) Pfam (PF19285) UniProt (by SIFTS) (P0ABE7) UniProt (by SIFTS) (Q9GZQ4) | Homo sapiens (human) |
Sequence modifications
B: 7 - 345 (UniProt: P62873)
C: -23 - 9 (UniProt: Q5H8A3)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Gly 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Leu 4 | - | expression tag |
| Leu 5 | - | expression tag |
| Gln 6 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gln 10 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 183211.2 | |
| All* | Total formula weight | 183211.2 |
