7W48
Crystal structure of the gastric proton pump complexed with PF-03716556
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Potassium-transporting ATPase alpha chain 1 | polymer | 1034 | 114456.7 | 1 | UniProt (P19156) Pfam (PF09040) Pfam (PF00690) Pfam (PF00122) Pfam (PF13246) Pfam (PF00702) Pfam (PF00689) | Sus scrofa (Pig) | Gastric H(+)/K(+) ATPase subunit alpha,Proton pump |
| 2 | B (B) | Potassium-transporting ATPase subunit beta | polymer | 290 | 33113.8 | 1 | UniProt (P18434) Pfam (PF00287) | Sus scrofa (Pig) | Gastric H(+)/K(+) ATPase subunit beta,Proton pump beta chain,gp60-90 |
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D, H (A) | O-DODECANYL OCTAETHYLENE GLYCOL | non-polymer | 538.8 | 2 | Chemie (CE1) | |||
| 5 | E, F, G (A) | RUBIDIUM ION | non-polymer | 85.5 | 3 | Chemie (RB) | |||
| 6 | I (A) | N-(2-hydroxyethyl)-N,2-dimethyl-8-[[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino]imidazo[1,2-a]pyridine-6-carboxamide | non-polymer | 394.5 | 1 | Chemie (8BZ) | |||
| 7 | J, K, L (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 8 | M (B) | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 1 | Chemie (PCW) |
Sequence modifications
A: 0 - 1033 (UniProt: P19156)
| PDB | External Database | Details |
|---|---|---|
| Cys 220 | Arg 221 | engineered mutation |
| Cys 593 | Ser 594 | engineered mutation |
| Ser 1005 | Gly 1006 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 147570.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 3203.4 | |
| All* | Total formula weight | 150774.0 |
