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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7W40

Cryo-EM Structure of Human Gastrin Releasing Peptide Receptor in complex with the agonist Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] and Gq heterotrimers

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Maltodextrin-binding protein,Gastrin-releasing peptide receptorpolymer89799534.11UniProt (A0A6D0N546)
UniProt (P30550)
Pfam (PF01547)
Pfam (PF00001)
UniProt (by SIFTS) (P0AEX9)		Escherichia coliGRP-R,GRP-preferring bombesin receptor
2B
(B)		Guanine nucleotide-binding protein G(q) subunit alphapolymer35341194.81UniProt (P50148)
Pfam (PF00503)		Homo sapiens (Human)Guanine nucleotide-binding protein alpha-q
3C
(C)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer38041398.11UniProt (P62873)
Pfam (PF00400)		Homo sapiens (Human)Transducin beta chain 1
4D
(D)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer819242.61UniProt (P59768)
Pfam (PF00631)		Homo sapiens (Human)G gamma-I
5E
(H)		ScFv16polymer30332785.61Homo sapiens
6F
(E)		Bombesinpolymer91118.31synthetic construct
Sequence modifications
A: -342 - 23 (UniProt: A0A6D0N546)
PDBExternal DatabaseDetails
Met -383-initiating methionine
Lys -382-expression tag
Thr -381-expression tag
Ile -380-expression tag
Ile -379-expression tag
Ala -378-expression tag
Leu -377-expression tag
Ser -376-expression tag
Tyr -375-expression tag
Ile -374-expression tag
Phe -373-expression tag
Cys -372-expression tag
Leu -371-expression tag
Val -370-expression tag
Phe -369-expression tag
Ala -368-expression tag
Asp -367-expression tag
Tyr -366-expression tag
Lys -365-expression tag
Asp -364-expression tag
Asp -363-expression tag
Asp -362-expression tag
Asp -361-expression tag
Lys -360-expression tag
His -359-expression tag
His -358-expression tag
His -357-expression tag
His -356-expression tag
His -355-expression tag
His -354-expression tag
His -353-expression tag
His -352-expression tag
His -351-expression tag
His -350-expression tag
Glu -349-expression tag
Asn -348-expression tag
Leu -347-expression tag
Tyr -346-expression tag
Phe -345-expression tag
Gln -344-expression tag
Gly -343-expression tag
Ala -171Glu 198engineered mutation
Ala -170Asn 199engineered mutation
Ala -104Lys 265engineered mutation
A: 24 - 341 (UniProt: P30550)
PDBExternal DatabaseDetails
Ala 157Ile 157engineered mutation
Gly 342-expression tag
Ser 343-expression tag
Ser 344-expression tag
Gly 345-expression tag
Gly 346-expression tag
Gly 347-expression tag
Gly 348-expression tag
Ser 349-expression tag
Gly 350-expression tag
Gly 351-expression tag
Gly 352-expression tag
Gly 353-expression tag
Ser 354-expression tag
Ser 355-expression tag
Gly 356-expression tag
Phe 357-expression tag
Thr 358-expression tag
Leu 359-expression tag
Glu 360-expression tag
Asp 361-expression tag
Phe 362-expression tag
Val 363-expression tag
Gly 364-expression tag
Asp 365-expression tag
Trp 366-expression tag
Glu 367-expression tag
Gln 368-expression tag
Thr 369-expression tag
Ala 370-expression tag
Ala 371-expression tag
Tyr 372-expression tag
Asn 373-expression tag
Leu 374-expression tag
Asp 375-expression tag
Gln 376-expression tag
Val 377-expression tag
Leu 378-expression tag
Glu 379-expression tag
Gln 380-expression tag
Gly 381-expression tag
Gly 382-expression tag
Val 383-expression tag
Ser 384-expression tag
Ser 385-expression tag
Leu 386-expression tag
Leu 387-expression tag
Gln 388-expression tag
Asn 389-expression tag
Leu 390-expression tag
Ala 391-expression tag
Val 392-expression tag
Ser 393-expression tag
Val 394-expression tag
Thr 395-expression tag
Pro 396-expression tag
Ile 397-expression tag
Gln 398-expression tag
Arg 399-expression tag
Ile 400-expression tag
Val 401-expression tag
Arg 402-expression tag
Ser 403-expression tag
Gly 404-expression tag
Glu 405-expression tag
Asn 406-expression tag
Ala 407-expression tag
Leu 408-expression tag
Lys 409-expression tag
Ile 410-expression tag
Asp 411-expression tag
Ile 412-expression tag
His 413-expression tag
Val 414-expression tag
Ile 415-expression tag
Ile 416-expression tag
Pro 417-expression tag
Tyr 418-expression tag
Glu 419-expression tag
Gly 420-expression tag
Leu 421-expression tag
Ser 422-expression tag
Ala 423-expression tag
Asp 424-expression tag
Gln 425-expression tag
Met 426-expression tag
Ala 427-expression tag
Gln 428-expression tag
Ile 429-expression tag
Glu 430-expression tag
Glu 431-expression tag
Val 432-expression tag
Phe 433-expression tag
Lys 434-expression tag
Val 435-expression tag
Val 436-expression tag
Tyr 437-expression tag
Pro 438-expression tag
Val 439-expression tag
Asp 440-expression tag
Asp 441-expression tag
His 442-expression tag
His 443-expression tag
Phe 444-expression tag
Lys 445-expression tag
Val 446-expression tag
Ile 447-expression tag
Leu 448-expression tag
Pro 449-expression tag
Tyr 450-expression tag
Gly 451-expression tag
Thr 452-expression tag
Leu 453-expression tag
Val 454-expression tag
Ile 455-expression tag
Asp 456-expression tag
Gly 457-expression tag
Val 458-expression tag
Thr 459-expression tag
Pro 460-expression tag
Asn 461-expression tag
Met 462-expression tag
Leu 463-expression tag
Asn 464-expression tag
Tyr 465-expression tag
Phe 466-expression tag
Gly 467-expression tag
Arg 468-expression tag
Pro 469-expression tag
Tyr 470-expression tag
Glu 471-expression tag
Gly 472-expression tag
Ile 473-expression tag
Ala 474-expression tag
Val 475-expression tag
Phe 476-expression tag
Asp 477-expression tag
Gly 478-expression tag
Lys 479-expression tag
Lys 480-expression tag
Ile 481-expression tag
Thr 482-expression tag
Val 483-expression tag
Thr 484-expression tag
Gly 485-expression tag
Thr 486-expression tag
Leu 487-expression tag
Trp 488-expression tag
Asn 489-expression tag
Gly 490-expression tag
Asn 491-expression tag
Lys 492-expression tag
Ile 493-expression tag
Ile 494-expression tag
Asp 495-expression tag
Glu 496-expression tag
Arg 497-expression tag
Leu 498-expression tag
Ile 499-expression tag
Thr 500-expression tag
Pro 501-expression tag
Asp 502-expression tag
Gly 503-expression tag
Ser 504-expression tag
Met 505-expression tag
Leu 506-expression tag
Phe 507-expression tag
Arg 508-expression tag
Val 509-expression tag
Thr 510-expression tag
Ile 511-expression tag
Asn 512-expression tag
Ser 513-expression tag
B: 36 - 359 (UniProt: P50148)
PDBExternal DatabaseDetails
Met 7-initiating methionine
Gly 8-expression tag
Cys 9-expression tag
Thr 10-expression tag
Leu 11-expression tag
Ser 12-expression tag
Ala 13-expression tag
Glu 14-expression tag
Asp 15-expression tag
Lys 16-expression tag
Ala 17-expression tag
Ala 18-expression tag
Val 19-expression tag
Glu 20-expression tag
Arg 21-expression tag
Ser 22-expression tag
Lys 23-expression tag
Met 24-expression tag
Ile 25-expression tag
Asp 26-expression tag
Arg 27-expression tag
Asn 28-expression tag
Leu 29-expression tag
Arg 30-expression tag
Glu 31-expression tag
Asp 32-expression tag
Gly 33-expression tag
Glu 34-expression tag
Lys 35-expression tag
Gln 183Arg 183engineered mutation
Leu 209Gln 209engineered mutation
C: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -13-initiating methionine
His -12-expression tag
His -11-expression tag
His -10-expression tag
His -9-expression tag
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
His -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Gly 1-expression tag
Gly 341-expression tag
Ser 342-expression tag
Ser 343-expression tag
Gly 344-expression tag
Gly 345-expression tag
Gly 346-expression tag
Gly 347-expression tag
Ser 348-expression tag
Gly 349-expression tag
Gly 350-expression tag
Gly 351-expression tag
Gly 352-expression tag
Ser 353-expression tag
Ser 354-expression tag
Gly 355-expression tag
Val 356-expression tag
Ser 357-expression tag
Gly 358-expression tag
Trp 359-expression tag
Arg 360-expression tag
Leu 361-expression tag
Phe 362-expression tag
Lys 363-expression tag
Lys 364-expression tag
Ile 365-expression tag
Ser 366-expression tag
D: 2 - 71 (UniProt: P59768)
PDBExternal DatabaseDetails
Met -9-initiating methionine
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
His -3-expression tag
His -2-expression tag
His -1-expression tag
His 0-expression tag
His 1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight225273.6
All*Total formula weight225273.6
*Water molecules are not included.

246704

PDB entries from 2025-12-24

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