Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7W3Z

Cryo-EM Structure of Human Gastrin Releasing Peptide Receptor in complex with the agonist Gastrin Releasing Peptide and Gq heterotrimers

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AMaltodextrin-binding protein,Gastrin-releasing peptide receptorpolymer89799534.11UniProt (A0A6D0N546)
UniProt (P30550)
Pfam (PF01547)
Pfam (PF00001)
UniProt (by SIFTS) (P0AEX9)
In PDB		Escherichia coliGRP-R,GRP-preferring bombesin receptor
2LGastrin Releasing Peptide PRGNHWAVGHLM(NH2)polymer131375.61Pfam (PF02044)
UniProt (by SIFTS) (P07492)
In PDB		Homo sapiens
3BGuanine nucleotide-binding protein G(q) subunit alphapolymer35341194.81UniProt (P50148)
Pfam (PF00503)
In PDB		Homo sapiens (Human)Guanine nucleotide-binding protein alpha-q
4CGuanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer38041398.11UniProt (P62873)
Pfam (PF00400)
In PDB		Homo sapiens (Human)Transducin beta chain 1
5DGuanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer819242.61UniProt (P59768)
Pfam (PF00631)
In PDB		Homo sapiens (Human)G gamma-I
6HScFv16polymer30332785.61Homo sapiens
Sequence modifications
A: -342 - 23 (UniProt: A0A6D0N546)
PDBExternal DatabaseDetails
Met -383-initiating methionine
Lys -382-expression tag
Thr -381-expression tag
Ile -380-expression tag
Ile -379-expression tag
Ala -378-expression tag
Leu -377-expression tag
Ser -376-expression tag
Tyr -375-expression tag
Ile -374-expression tag
Phe -373-expression tag
Cys -372-expression tag
Leu -371-expression tag
Val -370-expression tag
Phe -369-expression tag
Ala -368-expression tag
Asp -367-expression tag
Tyr -366-expression tag
Lys -365-expression tag
Asp -364-expression tag
Asp -363-expression tag
Asp -362-expression tag
Asp -361-expression tag
Lys -360-expression tag
His -359-expression tag
His -358-expression tag
His -357-expression tag
His -356-expression tag
His -355-expression tag
His -354-expression tag
His -353-expression tag
His -352-expression tag
His -351-expression tag
His -350-expression tag
Glu -349-expression tag
Asn -348-expression tag
Leu -347-expression tag
Tyr -346-expression tag
Phe -345-expression tag
Gln -344-expression tag
Gly -343-expression tag
Ala -171Glu 198engineered mutation
Ala -170Asn 199engineered mutation
Ala -104Lys 265engineered mutation
A: 24 - 341 (UniProt: P30550)
PDBExternal DatabaseDetails
Ala 157Ile 157engineered mutation
Gly 342-expression tag
Ser 343-expression tag
Ser 344-expression tag
Gly 345-expression tag
Gly 346-expression tag
Gly 347-expression tag
Gly 348-expression tag
Ser 349-expression tag
Gly 350-expression tag
Gly 351-expression tag
Gly 352-expression tag
Gly 353-expression tag
Ser 354-expression tag
Ser 355-expression tag
Gly 356-expression tag
Phe 357-expression tag
Thr 358-expression tag
Leu 359-expression tag
Glu 360-expression tag
Asp 361-expression tag
Phe 362-expression tag
Val 363-expression tag
Gly 364-expression tag
Asp 365-expression tag
Trp 366-expression tag
Glu 367-expression tag
Gln 368-expression tag
Thr 369-expression tag
Ala 370-expression tag
Ala 371-expression tag
Tyr 372-expression tag
Asn 373-expression tag
Leu 374-expression tag
Asp 375-expression tag
Gln 376-expression tag
Val 377-expression tag
Leu 378-expression tag
Glu 379-expression tag
Gln 380-expression tag
Gly 381-expression tag
Gly 382-expression tag
Val 383-expression tag
Ser 384-expression tag
Ser 385-expression tag
Leu 386-expression tag
Leu 387-expression tag
Gln 388-expression tag
Asn 389-expression tag
Leu 390-expression tag
Ala 391-expression tag
Val 392-expression tag
Ser 393-expression tag
Val 394-expression tag
Thr 395-expression tag
Pro 396-expression tag
Ile 397-expression tag
Gln 398-expression tag
Arg 399-expression tag
Ile 400-expression tag
Val 401-expression tag
Arg 402-expression tag
Ser 403-expression tag
Gly 404-expression tag
Glu 405-expression tag
Asn 406-expression tag
Ala 407-expression tag
Leu 408-expression tag
Lys 409-expression tag
Ile 410-expression tag
Asp 411-expression tag
Ile 412-expression tag
His 413-expression tag
Val 414-expression tag
Ile 415-expression tag
Ile 416-expression tag
Pro 417-expression tag
Tyr 418-expression tag
Glu 419-expression tag
Gly 420-expression tag
Leu 421-expression tag
Ser 422-expression tag
Ala 423-expression tag
Asp 424-expression tag
Gln 425-expression tag
Met 426-expression tag
Ala 427-expression tag
Gln 428-expression tag
Ile 429-expression tag
Glu 430-expression tag
Glu 431-expression tag
Val 432-expression tag
Phe 433-expression tag
Lys 434-expression tag
Val 435-expression tag
Val 436-expression tag
Tyr 437-expression tag
Pro 438-expression tag
Val 439-expression tag
Asp 440-expression tag
Asp 441-expression tag
His 442-expression tag
His 443-expression tag
Phe 444-expression tag
Lys 445-expression tag
Val 446-expression tag
Ile 447-expression tag
Leu 448-expression tag
Pro 449-expression tag
Tyr 450-expression tag
Gly 451-expression tag
Thr 452-expression tag
Leu 453-expression tag
Val 454-expression tag
Ile 455-expression tag
Asp 456-expression tag
Gly 457-expression tag
Val 458-expression tag
Thr 459-expression tag
Pro 460-expression tag
Asn 461-expression tag
Met 462-expression tag
Leu 463-expression tag
Asn 464-expression tag
Tyr 465-expression tag
Phe 466-expression tag
Gly 467-expression tag
Arg 468-expression tag
Pro 469-expression tag
Tyr 470-expression tag
Glu 471-expression tag
Gly 472-expression tag
Ile 473-expression tag
Ala 474-expression tag
Val 475-expression tag
Phe 476-expression tag
Asp 477-expression tag
Gly 478-expression tag
Lys 479-expression tag
Lys 480-expression tag
Ile 481-expression tag
Thr 482-expression tag
Val 483-expression tag
Thr 484-expression tag
Gly 485-expression tag
Thr 486-expression tag
Leu 487-expression tag
Trp 488-expression tag
Asn 489-expression tag
Gly 490-expression tag
Asn 491-expression tag
Lys 492-expression tag
Ile 493-expression tag
Ile 494-expression tag
Asp 495-expression tag
Glu 496-expression tag
Arg 497-expression tag
Leu 498-expression tag
Ile 499-expression tag
Thr 500-expression tag
Pro 501-expression tag
Asp 502-expression tag
Gly 503-expression tag
Ser 504-expression tag
Met 505-expression tag
Leu 506-expression tag
Phe 507-expression tag
Arg 508-expression tag
Val 509-expression tag
Thr 510-expression tag
Ile 511-expression tag
Asn 512-expression tag
Ser 513-expression tag
B: 36 - 359 (UniProt: P50148)
PDBExternal DatabaseDetails
Met 7-initiating methionine
Gly 8-expression tag
Cys 9-expression tag
Thr 10-expression tag
Leu 11-expression tag
Ser 12-expression tag
Ala 13-expression tag
Glu 14-expression tag
Asp 15-expression tag
Lys 16-expression tag
Ala 17-expression tag
Ala 18-expression tag
Val 19-expression tag
Glu 20-expression tag
Arg 21-expression tag
Ser 22-expression tag
Lys 23-expression tag
Met 24-expression tag
Ile 25-expression tag
Asp 26-expression tag
Arg 27-expression tag
Asn 28-expression tag
Leu 29-expression tag
Arg 30-expression tag
Glu 31-expression tag
Asp 32-expression tag
Gly 33-expression tag
Glu 34-expression tag
Lys 35-expression tag
Gln 183Arg 183engineered mutation
Leu 209Gln 209engineered mutation
C: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -13-initiating methionine
His -12-expression tag
His -11-expression tag
His -10-expression tag
His -9-expression tag
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
His -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Gly 1-expression tag
Gly 341-expression tag
Ser 342-expression tag
Ser 343-expression tag
Gly 344-expression tag
Gly 345-expression tag
Gly 346-expression tag
Gly 347-expression tag
Ser 348-expression tag
Gly 349-expression tag
Gly 350-expression tag
Gly 351-expression tag
Gly 352-expression tag
Ser 353-expression tag
Ser 354-expression tag
Gly 355-expression tag
Val 356-expression tag
Ser 357-expression tag
Gly 358-expression tag
Trp 359-expression tag
Arg 360-expression tag
Leu 361-expression tag
Phe 362-expression tag
Lys 363-expression tag
Lys 364-expression tag
Ile 365-expression tag
Ser 366-expression tag
D: 2 - 71 (UniProt: P59768)
PDBExternal DatabaseDetails
Met -9-initiating methionine
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
His -3-expression tag
His -2-expression tag
His -1-expression tag
His 0-expression tag
His 1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight225530.9
All*Total formula weight225530.9
*Water molecules are not included.

222415

PDB entries from 2024-07-10

PDB statisticsPDBj update infoContact PDBjnumon